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Wiping out childhood ear infections


June 2021

Plasma secretory phospholipase A2 as an early marker for late-onset sepsis in preterm infants—a pilot study

Preterm infants are particularly susceptible to bacterial late-onset sepsis (LOS). Diagnosis by blood culture and inflammatory markers have sub-optimal sensitivity and specificity and prolonged reporting times. There is an urgent need for more rapid, accurate adjunctive diagnostics in LOS to improve management and minimise antibiotic exposure.

Vaccine Trials Group Bacterial Respiratory Infectious Disease Group Neonatal Infection and Immunity
January 2021

Optimising a 6-plex tetanus-diphtheria-pertussis fluorescent bead-based immunoassay

Small volume assays are required for large-scale research studies and in particular paediatric trials, where multiple measures are required from a single sample. Fluorescent bead-based technology (Bioplex/Luminex) allows high through-put and simultaneous quantification of multiple analytes in a single test. This technology uses sets of microspheres, each with a unique spectral address that can be coated with a different antigen of interest.

Published research Immunisation Whooping Cough Vaccine Trials Group Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Bacterial Respiratory Infectious Disease Group
March 2020

Panel 8: Vaccines and immunology

Review and highlight of the significant advances made towards vaccine development and understanding of the immunology of otitis media

Published research Infectious Diseases Bacterial Respiratory Infectious Disease Group