Skip to content

At the Telethon Kids Institute our researchers are searching for answers to improve the health and wellbeing of children and families affected by some of  the most devastating, complex and common diseases and issues.  At any one time we have more than 200 active research projects and 700 staff and students that include laboratory scientists, clinicians, epidemiologists, bioinformaticians, statisticians, public health professionals and social scientists.

Our research is structured into Research Focus Areas, programs of work and teams.  We are committed to collaboration and work together with other research organisations, clinicians, practitioners, policy makers, consumers and the community to understand the complexity of factors that impact on a child's health and wellbeing and the translation of research findings into action. We actively reward research excellence and offer a range of schemes to support our researchers.

In August 2018, we moved to our new purpose-built facility located within Perth Children’s Hospital on the QEII Medical Centre campus - the largest centre of excellence in healthcare, research and education in the southern hemisphere. With a footprint across seven floors, our new home features more than 7000sqm of work space and 2000sqm of laboratories (including specialty suites, equipment rooms and freezer farms), as well as dedicated clinical suites and a cryogenics facility. Our co-location with the Perth Children’s Hospital will enhance our collaboration with clinicians, nursing staff and other allied health professionals, leading to better care, better treatments and better health and development outcomes for our children and young people.

We are an independent medical research institute based in Perth, Western Australia and affiliated with the State's major universities. Our research is  primarily funded through national and international competitive grants and generously supported by donors and governments.

Study subsites

Check out our study websites


Clinical Implications of Minimal Residual Disease Detection in Infants With KMT2A-Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of KMT2A gene rearrangements and poor outcome. We evaluated the value of minimal residual disease (MRD) in infants with KMT2A-rearranged ALL treated within the Interfant-06 protocol, which compared lymphoid-style consolidation (protocol IB) versus myeloid-style consolidation (araC, daunorubicin, etoposide/mitoxantrone, araC, etoposide).

Children's Cancers Published research Subsite: Cancer

Topical treatment of vulvodynia, dyspareunia and pudendal neuralgia: A single clinic audit of amitriptyline and oestriol in organogel

Vulvodynia and pudendal neuralgia comprise significant contributors to vulvar-related pain and its impact on daily life. A retrospective clinical audit was conducted at the Women's Health & Research Institute of Australia, Sydney, to determine the pattern of use and the efficacy of the application of topical amitriptyline 0.5% plus oestriol 0.03% in organogel (AOO), to the vulvar vestibule in reducing the impact of pain on daily life.

Published research Academic Biostatistics

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo.

Children's Cancers Published research Subsite: Cancer

Prenatal alcohol and tobacco use and the risk of depression in offspring at age of 17 years: findings from the Raine Study

Prenatal alcohol and tobacco exposures have been associated with adverse mental health consequences in offspring. The objective of this study was to test the associations between maternal prenatal alcohol and tobacco exposures and depressive symptoms in the offspring, adjusting for a wide range of potential confounders.

Published research

Glenn Pearson

Deputy Director, Aboriginal Health

BA (Education) PhD Candidate

Stephen Zubrick

Research Focus Area Head, Brain and Behaviour


Liz Davis

Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity Research


Deborah Strickland

Research Focus Area Head, Early Environment