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Protecting children against food allergies
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Reports and Findings
Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life
Neonates have heightened susceptibility to infections. The biological mechanisms are incompletely understood but thought to be related to age-specific adaptations in immunity due to resource constraints during immune system development and growth. We present here an extended analysis of our proteomics study of peripheral blood-plasma from a study of healthy full-term newborns delivered vaginally, collected at the day of birth and on day of life (DOL) 1, 3, or 7, to cover the first week of life. The plasma proteome was characterized by LC-MS using our established 96-well plate format plasma proteomics platform.
Published research Infectious Diseases Allergy & Infectious Diseases Vaccine Trials GroupWhole-Cell Pertussis Vaccination and Decreased Risk of IgE-Mediated Food Allergy: A Nested Case-Control Study
Australian infants who received whole-cell pertussis vaccines were less likely to be diagnosed with food allergy in childhood
Published research Immunisation Human Immunology Infectious Disease Implementation Research Vaccine Trials Group Food AllergyPlasma cytokine profiles in very preterm infants with late-onset sepsis
Very preterm infants have a marked innate inflammatory response at the time of late-onset sepsis
Vaccine Trials Group Neonatal Gut Health, Nutrition and Development Neonatal Infection and ImmunityClinical protocol for a longitudinal cohort study to identify markers of vaccine immunogenicity in newborn infants in the gambia and papua New Guinea
Immunity is distinct in early life and greater precision is required in our understanding of mechanisms of early life protection to inform development of new pediatric vaccines
Published research Immunisation Infectious Diseases Vaccine Trials Group