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Superbugs on 7 News
Protecting children against food allergies
What is pneumococcal disease?
Reports and Findings
Plasma secretory phospholipase A2 as an early marker for late-onset sepsis in preterm infants—a pilot study
Preterm infants are particularly susceptible to bacterial late-onset sepsis (LOS). Diagnosis by blood culture and inflammatory markers have sub-optimal sensitivity and specificity and prolonged reporting times. There is an urgent need for more rapid, accurate adjunctive diagnostics in LOS to improve management and minimise antibiotic exposure.
Vaccine Trials Group Bacterial Respiratory Infectious Disease Group Neonatal Infection and ImmunitySchool-based HPV vaccination positively impacts parents’ attitudes toward adolescent vaccination
This qualitative study aimed to explore parental attitudes, knowledge and decision-making about HPV vaccination for adolescents in the context of a gender-neutral school-based Australian National Immunisation Program (NIP). Semi-structured interviews with parents of adolescents eligible for HPV vaccination were undertaken as part of an evaluation of a cluster-randomised controlled trial of a complex intervention in 40 schools (2013-2015).
Published research Immunisation Vaccine Trials GroupPCV10 elicits Protein D IgG responses in Papua New Guinean children but has no impact on NTHi carriage in the first two years of life
Nasopharyngeal colonisation with nontypeable Haemophilus influenzae (NTHi) is associated with development of infections including pneumonia and otitis media. The 10-valent pneumococcal conjugate vaccine (PCV10) uses NTHi Protein D (PD) as a carrier. Papua New Guinean children have exceptionally early and dense NTHi carriage, and high rates of NTHi-associated disease.
Published research Immunisation Influenza Ear Health Vaccine Trials Group Subsite: Wesfarmers Centre of Vaccines and Infectious DiseasesOptimising a 6-plex tetanus-diphtheria-pertussis fluorescent bead-based immunoassay
Small volume assays are required for large-scale research studies and in particular paediatric trials, where multiple measures are required from a single sample. Fluorescent bead-based technology (Bioplex/Luminex) allows high through-put and simultaneous quantification of multiple analytes in a single test. This technology uses sets of microspheres, each with a unique spectral address that can be coated with a different antigen of interest.
Published research Immunisation Whooping Cough Vaccine Trials Group Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Bacterial Respiratory Infectious Disease Group