Wal-yan Respiratory Research Centre
Team
P4 Respiratory Health for Kids projects
Reports and Findings
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO
Ellis van Creveld syndrome and Weyers acrofacial dysostosis are two rare genetic diseases affecting skeletal development. They are both ciliopathies, as they are due to malfunction of primary cilia, microtubule-based plasma membrane protrusions that function as cellular antennae and are required for Hedgehog signaling, a key pathway during skeletal morphogenesis.
Published research P4 Respiratory Health for Kids Subsite: WalyanInsights into the associations between the gut microbiome, its metabolites and heart failure
Heart failure (HF) is the end stage of most cardiovascular diseases and remains a significant health problem globally. We aimed to assess whether patients with left ventricular ejection fraction ≤45% had alterations in both the gut microbiome profile and production of associated metabolites when compared to a healthy cohort.
Published research P4 Respiratory Health for Kids Subsite: WalyanStability Considerations for Bacteriophages in Liquid Formulations Designed for Nebulization
Pulmonary bacterial infections present a significant health risk to those with chronic respiratory diseases including cystic fibrosis and chronic-obstructive pulmonary disease. With the emergence of antimicrobial resistance, novel therapeutics are desperately needed to combat the emergence of resistant superbugs.
Cystic Fibrosis Published research Airway Epithelial Research P4 Respiratory Health for Kids Subsite: Walyan Respiratory viral infectionsRhinoviruses A and C elicit long-lasting antibody responses with limited cross-neutralization
Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types with little information about cross-neutralization. We previously showed that neutralizing antibody (nAb) responses to RV-C are detected twofold to threefold more often than those to RV-A throughout childhood. Based on those findings, we hypothesized that RV-C infections are more likely to induce either cross-neutralizing or longer-lasting antibody responses compared with RV-A infections.
Published research Infectious Diseases Human Immunology P4 Respiratory Health for Kids Children’s Respiratory Science Immune system