Featured Projects
In partnership with Derbarl Yerrigan Health Service and the Broome Regional Aboriginal Medical Service, we aim to improve Aboriginal lung health by determining for the first time the baseline lung function of Aboriginal Australians.
We hope that through earlier diagnosis and treatment of muscle weakness during sleep, we can prevent future lung failure in children with neuromuscular disorders.
Understanding if ongoing inflammation in the lungs contributes to the poor lung health experienced by some children who were born preterm.
Lung damage in children with CF occurs much earlier than previously thought, and proving this is related to the decline that occurs later will create new paradigms for prevention and treatment.
Many Healthy Lungs
Project
Wal-yan Respiratory Research Centre
Team
Children's Lung Health projects
Lung damage in children with CF occurs much earlier than previously thought, and proving this is related to the decline that occurs later will create new paradigms for prevention and treatment.
Past Projects
Children's lung health videos
AREST CF
Reports and Findings
Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants
Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity.
Children's Lung Health Chronobiology Subsite: WalyanOscillometry and spirometry are not interchangeable when assessing the bronchodilator response in children and young adults born preterm
The European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in clinical practice. The understanding of bronchodilator-induced oscillometry changes in preterm lung disease is poor. Here we describe a comparison of bronchodilator assessments performed using oscillometry and spirometry in a population born very preterm and explore the relationship between bronchodilator-induced changes in respiratory function and clinical outcomes.
Published research Early Childhood Development Children's Lung Health Subsite: Walyan Pre-term birthThe cost of respiratory hospitalizations in children with cerebral palsy
To establish the burden of respiratory illness in cerebral palsy (CP) on the Western Australian health care system by quantifying the costs of respiratory hospitalizations in children with CP, compared with non-respiratory hospitalizations.
Cerebral Palsy Published research Early Childhood Development Child Disability Children's Lung Health Child disability Kids Rehab Research WAInhaled corticosteroids to improve lung function in children (aged 6–12 years) who were born very preterm (PICSI): a randomised, double-blind, placebo-controlled trial
Despite the substantial burden of lung disease throughout childhood in children who were born very preterm, there are no evidence-based interventions to improve lung health beyond the neonatal period. We tested the hypothesis that inhaled corticosteroid improves lung function in this population.
Early Childhood Development Children's Lung Health Subsite: Walyan COVID-19 Pre-term birth Immune system