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February 2023

Ventilatory response and stability of oxygen saturation during a hypoxic challenge in very preterm infants

Preterm infants have immature control of breathing and impaired pulmonary gas exchange. We hypothesized that infants with bronchopulmonary dysplasia (BPD) have a blunted ventilatory response and peripheral oxygen saturation (SpO2 ) instability during a hypoxic challenge.

Published research Children's Lung Health Neonatal Cardiorespiratory Health Subsite: Walyan Pre-term birth
November 2022

Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity.

Published research Children's Lung Health Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Subsite: END RHD Invasive Streptococcus A Disease Healthy Skin and ARF Prevention BREATH Strep A Pathogenesis and Diagnostics
October 2022

The ventilatory response to hypoxia is blunted in some preterm infants during the second year of life

Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.

Published research Children's Lung Health Neonatal Infection and Immunity Pre-term birth