Wal-yan Respiratory Research Centre
WAERP
Team
Airway Epithelial Research projects
Reports and Findings
Tracing the transmission of mpox through wastewater surveillance in Southeast Asia
High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.
Published research Infectious Diseases Airway Epithelial Research Subsite: WalyanStability Considerations for Bacteriophages in Liquid Formulations Designed for Nebulization
Pulmonary bacterial infections present a significant health risk to those with chronic respiratory diseases including cystic fibrosis and chronic-obstructive pulmonary disease. With the emergence of antimicrobial resistance, novel therapeutics are desperately needed to combat the emergence of resistant superbugs.
Cystic Fibrosis Published research Airway Epithelial Research P4 Respiratory Health for Kids Subsite: Walyan Respiratory viral infectionsInterferon β-1a ring prophylaxis to reduce household transmission of SARS-CoV-2: a cluster randomised clinical trial
Accumulating evidence indicates that an early, robust type 1 interferon (IFN) response to SARS-CoV-2 is important in determining COVID-19 outcomes, with an inadequate IFN response associated with disease severity. Our objective was to examine the prophylactic potential of IFN administration to limit viral transmission.
Published research Infectious Diseases Airway Epithelial Research P4 Respiratory Health for Kids Subsite: Walyan Systems Vaccinology COVID-19Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing Klebsiella pneumoniae infections
Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is an important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam or ceftazidime-avibactam in vitro and in vivo against diverse CPKp clinical isolates.
Published research Infectious Diseases Airway Epithelial Research P4 Respiratory Health for Kids Subsite: Walyan