The SJ Elliot Cancer Trial
Three-continent clinical trial aims to improve survival for aggressive kids’ brain cancer
Team
Brain Tumour Research projects
Reports and Findings
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status
PTEN mutation occurs in a variety of aggressive cancers and is associated with poor patient outcomes. Recent studies have linked mutational loss of PTEN to reduced RAD51 expression and function, a key factor involved in the homologous recombination (HR) pathway. However, these studies remain controversial, as they fail to establish a definitive causal link to RAD51 expression that is PTEN-dependent, while other studies have not been able to recapitulate the relationship between the PTEN expression and the RAD51/HR function.
Published research Brain Tumour Research Subsite: CancerWhole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations.
Children's Cancers Published research Brain Tumour Research Subsite: CancerImmunogenicity of the inactivated influenza vaccine in children who have undergone allogeneic haematopoietic stem cell transplant
This study provides evidence to support annual inactivated influenza vaccine administration to children following allogeneic haematopoietic stem cell transplant
Children's Cancers Published research Academic Biostatistics Infectious Diseases Epidemiology Brain Tumour Research Leukaemia and Cancer GeneticsGermline Elongator mutations in Sonic Hedgehog medulloblastoma
Genetic predisposition to proteome instability may be a determinant in the pathogenesis of paediatric brain cancers
Children's Cancers Published research Brain Tumour Research