Senior Postdoctoral Researcher
BSc (Hons), PhD
Dr Jacqueline Whitehouse is a post-doctoral researcher in the Brain Tumour Research Program at Telethon Kids Institute. She completed a double major in Biomedical Science and Molecular Biology at Murdoch University before undertaking an Honours project in Immunology. She completed her PhD through the University of Western Australia and Telethon Kids Institute studying the immunological effects of ultraviolet light on asthmatic responses before changing fields in 2011 to work in paediatric brain cancer research. She was awarded the Elliot Parish Postdoctoral Fellowship for Child Cancer Research in 2015.
In her current role, Jacqueline helped develop a preclinical drug discovery pipeline that led to a clinical trial for children with relapsed/refractory medulloblastoma. Her work focuses on characterising patient-derived models of paediatric brain cancer, which can be used to identify which new treatments will benefit which patients. Complementing her drug discovery work, she has also established preclinical MRI techniques that evaluate the impact of these treatments on developing brains to ensure that only the safest agents are taken forward to clinical trial.
In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma
Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14 years. Moreover, a proportion of patients who survive treatment often suffer long-term neurological side effects as a result of therapy. It is evident that there is a need for safer, more effective treatments for pediatric EPN patients.Children's Cancers Published research Brain Tumour Research
Education and Qualifications