Cancer Centre
Team
Translational Genomics in Leukaemia projects
Reports and Findings
Insights into the Clinical, Biological and Therapeutic Impact of Copy Number Alteration in Cancer
Copy number alterations (CNAs), resulting from the gain or loss of genetic material from as little as 50 base pairs or as big as entire chromosome(s), have been associated with many congenital diseases, de novo syndromes and cancer. It is established that CNAs disturb the dosage of genomic regions including enhancers/promoters, long non-coding RNA and gene(s) among others, ultimately leading to an altered balance of key cellular functions.
Children's Cancers Published research Leukaemia Translational Research Translational Genomics in LeukaemiaThe ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program
Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled ETO2 depletion models. We demonstrate that beyond its well-established repressive activity, ETO2 directly activates transcription of MYB, among other genes.
Children's Cancers Published research Translational Genomics in LeukaemiaDown syndrome and leukemia: from basic mechanisms to clinical advances
Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades.
Children's Cancers Published research Subsite: Cancer Translational Genomics in Leukaemia Child disabilityA biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial.
Children's Cancers Published research Subsite: Cancer Translational Genomics in Leukaemia Genetics