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Celebrating 100 years of Immunology & Cell Biology – a special focus on the field of tumor immunology in Australia
In this Commentary article, as part of the 100-year celebrations of the journal, we reflect on the contribution of articles published in ICB in the field of tumor immunology. A highlight is a series of interviews conducted with three Australian-based ICB authors who have contributed key papers over the years: Rajiv Khanna, Delia Nelson and Ian Frazer.
Children's Cancers Published research Subsite: Cancer Sarcoma Translational ResearchA surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence
Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects.
Children's Cancers Published research Subsite: Cancer Sarcoma Translational Research Translational GeneticsGeldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma
Mesothelioma is characterised by its aggressive invasive behaviour, affecting the surrounding tissues of the pleura or peritoneum. We compared an invasive pleural model with a non-invasive subcutaneous model of mesothelioma and performed transcriptomic analyses on the tumour samples.
Children's Cancers Published research Systems Immunology Airway Epithelial Research Subsite: Cancer Sarcoma Translational ResearchStimulation of alpha-1 adrenoceptors may intensify cutaneous inflammation in complex regional pain syndrome
Alpha-1 adrenoceptors are overexpressed in the epidermis of a subgroup of patients with complex regional pain syndrome. Activating α 1 -adrenoceptors in epidermal cells increases production of the proinflammatory cytokine interleukin-6, a mediator of inflammation.
Published research Sarcoma Translational Research