Postdoctoral Researcher, Sarcoma Translational Research
BSc, PhD
Dr. Ben Wylie is a passionate immunologist and cancer researcher working as part of the Sarcoma Translational Research group in the Telethon Kids Cancer Centre. Ben has spent over 10 years developing and testing new cancer treatments, with a focus on immunotherapy, and has unique experience across both drug development and academic research.
His research interests include understanding how the immune system can detect and destroy cancer cells and how we can use this knowledge to design better therapies. Ben is currently working to develop safer and more effective treatments for kids with sarcoma.
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Publications
September 2021
IFNβ Is a Potent Adjuvant for Cancer Vaccination Strategies
Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the role of individual subtypes remains unclear. Here we systematically compared the capacity of distinct type I IFN subtypes to enhance T cell responses to a whole-cell vaccination strategy in a pre-clinical murine model.
Children's Cancers Published research Immunisation Systems Immunology Cancer Immunotherapy Subsite: Cancer Translational Genetics Immune systemSeptember 2021Temporally restricted activation of IFNβ signaling determines response to immune checkpoint therapy
The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients.
Children's Cancers Published research Computational Biology Sarcoma Translational Research Translational GeneticsDecember 2021Targeting cross-presentation as a route to improve the efficiency of peptide-based cancer vaccines
Cross-presenting dendritic cells (DC) offer an attractive target for vaccination due to their unique ability to process exogenous antigens for presentation on MHC class I molecules. Recent reports have established that these DC express unique surface receptors and play a critical role in the initiation of anti-tumor immunity, opening the way for the development of vaccination strategies specifically targeting these cells.
Children's Cancers Published research Cancer Immunotherapy Sarcoma Translational Research