Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

In partnership with Derbarl Yerrigan Health Service and the Broome Regional Aboriginal Medical Service, we aim to improve Aboriginal lung health by determining for the first time the baseline lung function of Aboriginal Australians. ...

• 1. Telethon Kids Institute
• Projects

Community Connection Perth mother-of-four and Tiny Sparks WA co-founder Amber Bates is on the PELICAN Scientific Steering Committee with Dr Simpson. ...

• 1. Telethon Kids Institute
• Our research
• Research Impact
• 2021
• Collaboration

A previous systematic review showed that intramuscular vitamin A supplementation reduced the risk of bronchopulmonary dysplasia (BPD) in very-low-birth-weight (VLBW) infants. However, more recent studies have questioned this finding. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Preterm infants have immature control of breathing and impaired pulmonary gas exchange. We hypothesized that infants with bronchopulmonary dysplasia (BPD) have a blunted ventilatory response and peripheral oxygen saturation (SpO2 ) instability during a hypoxic challenge. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Exhaled breath condensate (EBC) collection is a non-invasive, safe method for measurement of biomarkers in patients with lung disease. Other methods of obtaining samples from the lungs, such as bronchoalveolar lavage, are invasive and require anaesthesia/sedation in neonates and infants. EBC is particularly appealing for assessing biomarkers in preterm-born infants, a population at risk of ongoing lung disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

Next steps Did you know? Further studies are needed to determine how to predict which kids will benefit the most from this intervention, and to ...

• 1. Telethon Kids Institute
• Our research
• Research Impact
• 2023
• Paradigm shift

Lung function trajectories are impaired in survivors of very preterm birth ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

A new study has found a common asthma drug is effective for some very premature babies who go on to suffer from lung complications. ...

• Wal-yan Respiratory Research Centre
• News & events
• 2023
• July

Bronchopulmonary dysplasia (BPD) remains the most common complication of preterm birth with lifelong consequences. Multiple BPD definitions are currently used in daily practice. Uniformity in defining BPD is important for clinical care, research and benchmarking. The aim of this Delphi procedure is to determine what clinicians and researchers consider the key features for defining BPD. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023