Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Our current Research Topic highlights the complexity of the relationship between the skin, immune system and skin cancer ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

In this review, we discuss the different subsets of tumor-infiltrating dendritic cells and their role in anti-tumor immunity ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Our data demonstrate that CD8+XCR1neg DCs possess a unique pattern of endocytic receptors and a restricted TLR profile that is particularly enriched for TLR5 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

Data indicate a role for Interferonβ in linking viral infection and allergy ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

This report provides new insight into the functional specialization within the broad network of dendritic cells that are responsible for skin immunosurveillance ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• August 2015

This article investigates the impact of burn & excisional injury on the immune system. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• May 2015