Computational Biologist
BSc MSc PhD
Dr Anya Jones is a Computational Biologist at the Telethon Kids Institute and Adjunct Research Fellow at the University of Western Australia. Anya was awarded her PhD from the University of Western Australia (2018) in Systems Immunology. Her expertise lies in bridging the gap between immunology and bioinformatics. Anya uses a systems biology approach to decode childhood diseases (allergy, cancer) to develop better treatments. In the Wal-yan Respiratory Research Centre, Anya aims to identify the underlying mechanisms of allergen immunotherapy (dust mites/peanut). In the Telethon Kids Cancer Centre, Anya is researching diffuse midline gliomas (DMG, formerly known as DIPG), a rare and highly aggressive childhood brain cancer.
Find Dr Anya Jones on ORCID
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Publications
March 2022
Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets
Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes. To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the disease and the impact of current therapies are limited.
Children's Cancers Published research Brain Tumour Research Cancer Immunology and BiologyJuly 2022Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies
Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear.
Published research Pregnancy and Early Life Immunology Human Immunology Systems Immunology Immune system Respiratory viral infections Cancer Immunology and BiologyMay 2022Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks
The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes.
Published research Human Immunology Systems Immunology Food Allergy Computational Biology Allergy Cancer Immunology and BiologyDecember 2020Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming
We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis.
Published research Pregnancy and Early Life Immunology Human Immunology Systems ImmunologyNovember 2019Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles
the association between infant LRTI and risk for persistent wheeze/asthma in this cohort is generally stronger for fLRTIs than for other infection categories
Published research Pregnancy and Early Life Immunology Human Immunology Systems ImmunologySeptember 2019Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children
The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children
Asthma Published research Academic Biostatistics Pregnancy and Early Life Immunology Human Immunology Systems ImmunologyJune 2019Personalized transcriptomics reveals heterogeneous immunophenotypes in children with viral bronchiolitis
Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants
Published research Bronchiolitis Pregnancy and Early Life Immunology Human Immunology Systems ImmunologyNovember 2018Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations
Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations
Asthma Published research Pregnancy and Early Life Immunology Human Immunology Systems ImmunologyAugust 2018Atopy-dependent and independent immune responses in the heightened severity of atopics to respiratory viral infections: Rat model studies
The co-exposure responses in the Th2high BN incorporated type I interferon/Th1, alternative macrophage activation/Th2 and Th17 signatures
Published research Pregnancy and Early Life Immunology Human Immunology Systems Immunology