Team
Pregnancy and Early Life Immunology projects
Reports and Findings
Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life
Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group.
Published research Early Childhood Development Pregnancy and Early Life Immunology Human Immunology P4 Respiratory Health for Kids Respiratory viral infectionsProtection against severe infant lower respiratory tract infections by immune training: Mechanistic studies
Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear.
Published research Pregnancy and Early Life Immunology Human Immunology Systems Immunology Oncogenic Signalling Laboratory Immune system Respiratory viral infectionsAirway and parenchymal transcriptomics in a novel model of asthma and COPD overlap
Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap. Patients characterized with ACO have increased disease severity; however, the mechanisms driving this have not been widely studied.
Asthma Published research Pregnancy and Early Life Immunology Systems ImmunologyRetinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy
With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity.
Children's Cancers Published research Pregnancy and Early Life Immunology Systems Immunology Subsite: Cancer Sarcoma Translational Research