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        Research

        Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants

        Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity. ...

        Research

        Airway smooth muscle thickness and contraction are enhanced by intra-amniotic lipopolysaccharide in an ovine model of premature birth

        Abnormalities of the airway smooth muscle (ASM) layer in asthma may develop before birth. We hypothesize that antenatal inflammation causes physiological abnormalities of the ASM that predisposes asthma. This study determined the short-term effects of antenatal inflammation on the developing ASM. ...

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        Meet the Trial Management Team

        The CIRCA DIEM Trial Management Team Prof Jane Pillow BMedSci (Dist) MBBS, PhD (Dist) FRACP CIRCA DIEM Coordinating Principal Investigator, Research ...

        The CIRCA DIEM Sub-Studies

        MRI Sub-Study Sleep Sub-Study Infection and Immunology Sub-Study Social Communication Sub-study At some hospitals, babies may have a Magnetic ...

        Research

        The development and refinement of a sensitive bedside test to continually measure the severity of BPD and lung development in preterm infants

        Graham Jane Shannon Hall Pillow Simpson GL JP SS BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (Dist) MBBS, PhD (Dist) FRACP BMedSci (hons), PhD ...

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        Professor Jane Pillow

        Research Theme Head, Early Environment; Team Lead, Chronobiology ...

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        Research

        Pulmonary Gas Exchange Improves over the First Year in Preterm Infants with and without Bronchopulmonary Dysplasia

        Right shift of the peripheral oxyhaemoglobin saturation (SpO2) versus inspired oxygen pressure (PIO2) curve is a sensitive marker of pulmonary gas exchange. The aim of this study was to assess the impact of prematurity and bronchopulmonary dysplasia (BPD) on gas exchange and right-to-left shunt in the neonatal period, and its evolution over the first year of life. ...

        Research

        Positive End-Expiratory Pressure Levels during Resuscitation of Preterm Infants at Birth: The POLAR Trial

        Investigators: Andrew Gill External collaborators: Assoc Prof David Tingay (Murdoch Children's Research Institute) The POLAR trial is an MRFF-funded ...

        Participating Sites and Investigators

        Trial Steering Group Study Sites and Investigators Prof Jane Pillow Telethon Kids Institute and The University of Western Australia Prof Rod Hunt ...

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