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        Research

        Abacavir inhibits but does not cause self-reactivity to HLA-B*57:01-restricted EBV specific T cell receptors

        Pre-existing pathogen-specific memory T cell responses can contribute to multiple adverse outcomes including autoimmunity and drug hypersensitivity. How the specificity of the T cell receptor (TCR) is subverted or seconded in many of these diseases remains unclear. Here, we apply abacavir hypersensitivity (AHS) as a model to address this question because the disease is linked to memory T cell responses and the HLA risk allele, HLA-B*57:01, and the initiating insult, abacavir, are known. ...

        Research

        Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action

        Chemotherapy has historically been the mainstay of cancer treatment, but our understanding of what drives a successful therapeutic response remains limited. ...

        Research

        Experience of patients with lung cancer and with targeted therapy-related skin adverse drug reactions: A qualitative study

        To explore the experience of non-small-cell lung cancer patients with targeted therapy-related skin adverse drug reactions. ...

        Research

        Celebrating 100 years of Immunology & Cell Biology – a special focus on the field of tumor immunology in Australia

        In this Commentary article, as part of the 100-year celebrations of the journal, we reflect on the contribution of articles published in ICB in the field of tumor immunology. A highlight is a series of interviews conducted with three Australian-based ICB authors who have contributed key papers over the years: Rajiv Khanna, Delia Nelson and Ian Frazer. ...

        Research

        Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes

        Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response.  ...

        People

        Associate Professor W. Joost Lesterhuis

        Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head ...

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        Research

        Supportive care needs and associated factors among caregivers of patients with colorectal cancer: a cross-sectional study

        To assess the level of supportive care needs of caregivers of colorectal cancer patients and explore the related key influencing factors. Totaling 283 caregivers of patients with colorectal cancer were investigated in this study.  ...

        Sarcoma Translational Research

        We think all kids with Sarcoma should be able to lead happy, healthy lives! To achieve this, we aim to discover and develop safer and more effective treatments by doing inventive and rigorous research. We focus on addressing high relapse rates using a combination of unique pre-clinical models, patient samples and systems immunology. ...

        Research

        Caregiver burden, mutuality, and family resilience in colorectal cancer caring: A mediating model analysis

        This study investigates the interaction between caregiver burden, mutuality, and family resilience in colorectal cancer management, and determines whether mutuality affects the effect of caregiver burden on family resilience. ...

        Research

        Cancer Program

        Listed are all Telethon Kids Institute research teams involved in our Cancer Program. This program sits under the Chronic and Severe Diseases research theme. ...

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