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        Research

        Germ-line and somatic DICER1 mutations in pineoblastoma

        This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

        Research

        A pre-clinical model of resistance to induction therapy in pediatric acute lymphoblastic leukemia

        Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. ...

        Research

        Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis

        Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell... ...

        Research

        Comparative drug screening in NUT midline carcinoma

        The NUT midline carcinoma (NMC) is a rare but fatal cancer for which systematic testing of therapy options has never been performed. ...

        Research

        Pre-natal, clonal origin of t(1;11)(p32;q23) acute lymphoblastic leukemia in monozygotic twins

        Investigation of this rare mixed lineage leukemia cytogenetic abnormality aims to provide further evidence of the genetic changes that underpin this leukemia. ...

        Research

        Interactions between acute lymphoblastic leukemia and bone marrow stromal cells influence response to therapy

        The cure rate for pediatric patients with B precursor acute lymphoblastic leukemia (pre-B ALL) is steadily improving, however relapses do occur despite... ...

        Research

        Western Australian children with acute lymphoblastic leukemia are taller at diagnosis than unaffected children of the same age and sex

        Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy in Australian children ...

        Research

        Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells

        Human embryonic stem cell-derived neural stem cells (hESC-NSCs) are an attractive cell type for studying ...

        People

        Associate Professor Laurence Cheung

        Co-Head, Leukaemia Translational Research ...

        08 6319 1345 Email me
        Research

        Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia

        KMT2A-rearranged acute lymphoblastic leukemia (ALL) in infants is an aggressive disease with 3-year event-free survival below 40%. Most relapses occur during treatment, with two thirds occurring within 1 year and 90% within 2 years after diagnosis. Outcomes have not improved in recent decades despite intensification of chemotherapy. ...

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