Senior Research Officer, Leukaemia and Cancer Genetics
BPharm (Hons) MBA PhD
Laurence has a Bachelor of Pharmacy degree with First Class Honours and a MBA from Curtin University. In 2014, he completed his PhD studies at the Telethon Kids Institute in the area of haematopoiesis and paediatric leukaemia. He is currently supported by Children’s Leukaemia and Cancer Research Foundation and continues his research as a Senior Research Officer at Prof Kees’ Laboratory at the Telethon Kids Institute.
He is also working as a clinical trial governance pharmacist at Princess Margaret Hospital for Children and as a sessional academic at Curtin University and The University of Western Australia.
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Projects
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Publications
May 2020
Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma
IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition
Children's Cancers Published research Leukaemia and Cancer GeneticsJuly 2019Romidepsin enhances the efficacy of cytarabine in vivo, revealing HDAC inhibition as a therapeutic strategy for KMT2A-rearranged acute lymphoblastic leukemia
In this study, we investigate the in vivo synergy between romidepsin and cytarabine
Children's Cancers Published research Leukaemia and Cancer GeneticsMarch 2019Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemia
Our findings shed light on the mechanisms of leukemia-induced bone loss
Children's Cancers Published researchDecember 2018A novel, palatable paediatric oral formulation of midazolam: Pharmacokinetics, tolerability, efficacy and safety
We conclude that the novel chocolate-based formulation of midazolam provides improved tolerability while remaining efficacious
Published research Leukaemia and Cancer Genetics Children's Lung HealthNovember 2018New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment
We provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL
Children's Cancers Published research Leukaemia and Cancer GeneticsJanuary 2018Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles
This study utilized in vitro, in vivo and clinical data to evaluate the palatability of a novel midazolam chocolate tablet.
Published research Leukaemia and Cancer GeneticsJanuary 2017Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin
Identified romidepsin as a promising therapeutic for mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia
Children's Cancers Published research Academic Biostatistics Leukaemia and Cancer Genetics Computational BiologySeptember 2016High expression of connective tissue growth factor accelerates dissemination of leukaemia
Functional role of CTGF in altering disease progression in a lymphoid malignancy
Children's Cancers Published research Leukaemia and Cancer GeneticsJanuary 2016Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin
Present a valuable resource for drug discovery and have identified ROM as a promising therapeutic for MLL-rearranged iALL
Published research Leukaemia and Cancer Genetics Computational BiologyMay 2015The role of CCN family genes in haematological malignancies
Haematological malignancies, although a broad range of specific disease types, continue to show considerable overlap in classification, and patients are...
Children's Cancers Published research Leukaemia and Cancer GeneticsApril 2014Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis
Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell...
Children's Cancers Published research Experimental Immunology Leukaemia and Cancer Genetics -
Education and Qualifications
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