The aim of this study was to examine the gene response of white blood cells in severe allergic reactions to identify genes that could be targets to new drugs... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• July 2014

Alexander Anthony Deborah Emma Jean-Francois Pat Larcombe Kicic Strickland de Jong Lauzon-Joset Holt A A DH EdJ JFLJ PG BScEnv (Hons) PhD BSc (Hons) ...

• 1. Telethon Kids Institute
• Projects

Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter resulted in invasive and rapid growth. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Immunotherapy has revolutionised the treatment of cancers by harnessing the power of the immune system to eradicate malignant tissue. However, it is well recognised that some cancers are highly resistant to these therapies, which is in part attributed to the immunosuppressive landscape of the tumour microenvironment (TME). The contexture of the TME is highly heterogeneous and contains a complex architecture of immune, stromal, vascular and tumour cells in addition to acellular components such as the extracellular matrix. While understanding the dynamics of the TME has been instrumental in predicting durable responses to immunotherapy and developing new treatment strategies, recent evidence challenges the fundamental paradigms of how tumours can effectively subvert immunosurveillance. Here, we discuss the various immunosuppressive features of the TME and how fine-tuning these mechanisms, rather than ablating them completely, may result in a more comprehensive and balanced anti-tumour response. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Upper and lower airways are conserved in their transcriptional composition, and variations associated with disease are present in both nasal and tracheal epithelium ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

In this article, we examine the utility of a transdiagnostic, dimensional approach to very early identification and intervention for infants at risk of neurodevelopmental disorders ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

To introduce a disease prognosis framework enabled by a robust classification scheme derived from patient-specific transcriptomic response to stimulation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

Alexander David Deborah Larcombe Martino Strickland A DM DH BScEnv (Hons) PhD BSc PhD PhD Team Leader, Respiratory Environmental Health Team Leader, ...

• 1. Telethon Kids Institute
• Projects

Jean-Francois Lauzon-Joset JFLJ Senior Research Officer Jean-Francois (Jeff) Lauzon-Joset was awarded his PhD in 2014 from the Laval University ( ...

• 1. Telethon Kids Institute
• Contact us
• Our people
• Staff Profiles - L