Senior Research Officer
Jean-Francois (Jeff) Lauzon-Joset was awarded his PhD in 2014 from the Laval University (Quebec, Canada). He is now doing postdoctoral training at the Telethon Kids Institute with the Systems Immunology lab.
His interest includes the role of viral infection on asthma development, as well as the cellular mechanisms underlying severe viral infection.
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Publications
September 2023
In Vivo Evidence of Respiratory Syncytial Virus Persistence in a Subset of Pulmonary Dendritic Cells Following a Primary Infection
Respiratory syncytial virus (RSV) causes annual epidemics of infections affecting the whole population. In vitro, it has been shown to infect and persist in human dendritic cells (DCs) for prolonged periods. Initially persistence is associated with low levels of replication before the virus becomes dormant. Reactivation of viral replication can be triggered many months later.
Published research Early Childhood Development Infectious Diseases Pregnancy and Early Life Immunology Bacterial Respiratory Infectious Disease Group Respiratory viral infectionsJuly 2021IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming
High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype.
Asthma Published research Pregnancy and Early Life Immunology Inflammation Human Immunology Systems Immunology Respiratory Environmental HealthJuly 2021Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85
Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways.
Published research Early Childhood Development Pregnancy and Early Life Immunology Human Immunology Systems ImmunologyDecember 2020Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming
We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis.
Published research Pregnancy and Early Life Immunology Human Immunology Systems ImmunologyMarch 2020Nasal delivery of a commensal Pasteurellaceae species inhibits nontypeable Haemophilus influenzae colonisation and delays onset of otitis media in mice
We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo
Published research Ear Infections Infectious Diseases Pregnancy and Early Life Immunology Vaccine Trials Group Bacterial Respiratory Infectious Disease Group Healthy Skin and ARF PreventionMarch 2020Oestrogen amplifies pre-existing atopy-associated Th2 bias in an experimental asthma model
The role of oestrogen in experimental atopic asthma, and guide future research on sex-related variations in atopic asthma susceptibility/intensity
Published research Pregnancy and Early Life Immunology Human ImmunologyMarch 2019Quantification of Serum Ovalbumin-specific Immunoglobulin E Titre via in vivo Passive Cutaneous Anaphylaxis Assay
We describe herein a highly reproducible in vivo passive cutaneous anaphylaxis assay using Sprague Dawley rats for the quantification of ovalbumin-specific IgE
Published research Pregnancy and Early Life Immunology Human ImmunologyMarch 2019Early Life Ovalbumin Sensitization and Aerosol Challenge for the Induction of Allergic Airway Inflammation in a BALB/c Murine Model
This protocol adapted an experimental animal model of disease for sensitization to ovalbumin during the immediate post-weaning period beginning at 21 days of age
Published research Pregnancy and Early Life Immunology Human ImmunologyNovember 2018Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation
These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention
Published research Pregnancy and Early Life Immunology Human Immunology Respiratory Environmental HealthAugust 2018Atopy-dependent and independent immune responses in the heightened severity of atopics to respiratory viral infections: Rat model studies
The co-exposure responses in the Th2high BN incorporated type I interferon/Th1, alternative macrophage activation/Th2 and Th17 signatures
Published research Pregnancy and Early Life Immunology Human Immunology Systems Immunology