Investigators: Principal Investigator Associate Professor Asha Bowen, Associate Investigator Dr Anita Campbell, Associate Investigator Keerthi Anpalagan (PhD Candidate).
Project description:
There are an estimated 5000 episodes per year of bloodstream infections due to Staphylococcus aureus (golden staph) in Australia and an associated mortality of 20%. Despite this, there is little clinical trials evidence to guide best management.
The Staphylococcus aureus Network Adaptive Platform trial (SNAP) is the largest international clinical trial of its kind that will both establish best practice evidence and optimise care for patients during the conduct of the trial. The trial is currently recruiting neonates, the elderly and participants of all ages in between.
The study includes over 80 sites from Australia, New Zealand, Israel, the UK and has the potential to expand to other regions. Learn more here: https://www.snaptrial.com.au/
The SNAP-PY (SNAP – Paediatrics and Youth) Trial is the specific paediatric aspect of SNAP and is led by Associate Professor Asha Bowen at the Telethon Kids Institute.
Coming soon: SNOOPY sub-study. SNOOPY (Staphylococcus aureus Network; ultrasOund for diagnOsis of endovascular disease in Paediatrics and Youth) is a 1 year study that will evaluate the use of an imaging device (whole-body doppler ultrasound) to detect blood clots in children with golden staph bloodstream infections. SNOOPY aims to investigate how often clots occur in children with such infections, risk factors for clots and identify which children are at the highest risk. SNOOPY will also evaluate whether earlier detection and management of blood clots impacts clinical outcomes.
Partners: Perth Children's Hospital, University of Western Australia, Wesfarmers Centre of Vaccines & Infectious Diseases
External collaborators:
Global Coordinating Centre: University of Melbourne, Peter Doherty Institute for Infection and Immunity
Coordinating Principal Investigators: Professor Steven Tong (University of Melbourne), Professor Joshua Davis (Menzies School of Health Research)
Funders:
- Australian National Health and Medical Research Council (NHMRC) Clinical Trials and Cohort Studies Grant (Award IDs: APP1184238 & APP2014900)
- NHMRC Medical Research Future Fund (MRFF) International Clinical Trial Collaborations Grant (Award ID: APP2017301)
- Perth Children's Hospital Foundation: Provides local funding for participants recruited at Perth Children's Hospital
- Canadian Institutes of Health Research (CIHR; Award ID: 451092)
- Health and Research Council (HRC) Funding Grant (Improving Outcomes for Acute & Chronic Conditions in NZ (Reference ID: 19/680)
- National Institute for Health Research (NIHR) Health Technology Assessment Programme (ID: NIHR133719)
- Wesfarmers SEED Grant (SNOOPY)
- Kakulas Grant (SNOOPY)
- RCPA Foundation Kanematsu Research Award (SNOOPY)