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        Research

        Skin-Microbiome Assembly in Preterm Infants during the First Three Weeks of Life and Impact of Topical Coconut Oil Application

        The structure and function of infant skin is not fully developed until 34 weeks of gestation, and this immaturity is associated with risk of late-onset sepsis (LOS). Topical coconut oil improves preterm-infant skin integrity and may reduce LOS. However, data on early-life skin-microbiome succession and potential effects of emollient skin care in preterm infants are scarce. ...

        Research

        sPLA2 study: Immune ontogeny and prediction, prevention and management of late-onset sepsis in very preterm infants

        Tobias Strunk TS MD, PhD, FRACP Team leader, Neonatal Health tobias.strunk@telethonkids.org.au Team leader, Neonatal Health Clinical Professor Tobias ...

        Research

        Early Life & Life-Course Health

        Listed are the Telethon Kids Institute research teams involved in our Early Life & Life-Course Health Program. This program sits under the Early Environment research theme. ...

        Research

        The COSI-2 Trial

        Tobias Jenny Strunk Mountain TS JM MD, PhD, FRACP MBA MClinEpi Team leader, Neonatal Health Project Manager tobias.strunk@telethonkids.org.au Team ...

        Research

        Vitamin A supplementation in very-preterm or very-low-birth-weight infants to prevent morbidity and mortality: A systematic review and meta-Analysis of randomized trials

        A previous systematic review showed that intramuscular vitamin A supplementation reduced the risk of bronchopulmonary dysplasia (BPD) in very-low-birth-weight (VLBW) infants. However, more recent studies have questioned this finding. ...

        Research

        Plasma secretory phospholipase A2 as an early marker for late-onset sepsis in preterm infants—a pilot study

        Preterm infants are particularly susceptible to bacterial late-onset sepsis (LOS). Diagnosis by blood culture and inflammatory markers have sub-optimal sensitivity and specificity and prolonged reporting times. There is an urgent need for more rapid, accurate adjunctive diagnostics in LOS to improve management and minimise antibiotic exposure. ...

        Research

        Whole blood transcriptional responses of very preterm infants during late-onset sepsis

        Blood responses in very preterm infants with LOS are characterised by altered host immune responses that appear to reflect unbalanced immuno-metabolic homeostasis ...

        Research

        Gene filtering strategies for machine learning guided biomarker discovery using neonatal sepsis RNA-seq data

        Machine learning (ML) algorithms are powerful tools that are increasingly being used for sepsis biomarker discovery in RNA-Seq data. RNA-Seq datasets contain multiple sources and types of noise (operator, technical and non-systematic) that may bias ML classification. Normalisation and independent gene filtering approaches described in RNA-Seq workflows account for some of this variability and are typically only targeted at differential expression analysis rather than ML applications. ...

        Research

        Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology

        The highest incidence of sepsis across all age groups occurs in neonates leading to substantial mortality and morbidity. Cardiovascular dysfunction frequently complicates neonatal sepsis including biventricular systolic and/or diastolic dysfunction, vasoregulatory failure, and pulmonary arterial hypertension. ...

        Research

        A systems biology approach to better understand human tick-borne diseases

        Tick-borne diseases are a growing global health concern. Despite extensive studies, ill-defined tick-associated pathologies remain with unknown aetiologies. Human immunological responses after tick bite, and inter-individual variations of immune-response phenotypes, are not well characterised. ...

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