Program Head, Diabetes and Obesity
BSc (Hons) PhD
Shelley Gorman is a Group Leader at the Telethon Kids Institute with expertise in the effects of sun exposure and vitamin D on health. She investigates the mechanisms by which ultraviolet radiation modulates metabolic dysfunction, inflammation, and immunity. Through her research, Shelley aims to improve our understanding of biological processes modulated by sun exposure, which provide an evidence-base for research in humans and help health policy makers give better-informed sun exposure advice. Her team also aims to determine how early life environmental and nutritional exposures modulate immune and tissue development.
Shelley's research has identified that low dose sun exposure or induced mediators like nitric oxide could be used to treat obesity and associated cardiometabolic disorders like type-2 diabetes. Her published findings have also provided evidence for many ongoing clinical trials that test whether vitamin D supplementation can intervene in the progression of chronic disease.
Gorman was awarded a four-year Al and Val Rosenstrauss Fellowship from the Rebecca L Cooper Medical Research Foundation in 2016 to investigate how safe sun exposure might be harnessed to suppress the development of obesity and metabolic dysfunction. Her current research program involves the supervision and mentoring of PhD, Honours and MD students, as well as a number of student volunteers.
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Projects
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Publications
Jun 2023
The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
Prior to the coronavirus disease-19 pandemic, the germicidal effects of visible light were well known. This review provides an overview of new findings that suggest there are direct inactivating effects of visible light - particularly blue wavelengths on exposed severe acute respiratory syndrome coronavirus 2 virions, and inhibitory effects on viral replication in infected cells. These findings complement emerging evidence that there may be clinical benefits of orally administered blue light for limiting the severity of COVID-19.
Published research Infectious Diseases Cardiometabolic Sunhealth COVID-19August 2022A Gender Lens on User Quality Ratings From Young Teenagers Assessing the Sun Safe App: Comparing Responses From Co-researchers and Participants of Pilot Intervention Studies
We developed the iOS smartphone app Sun Safe to support healthy sun practices in young teenagers (aged 12-13 years). The production involved co-design with young co-researchers (ie, aged 12-13 years) with a health message of using sun protection when the UV index is ≥3. Important features include real-time and location-specific weather data on the UV index and gamified educational content.
Published research Vitamin D and Sunlight Cardiometabolic Sunhealth Food and NutritionNovember 2022Increased levels of solar radiation are associated with reduced type-2 diabetes prevalence: A cross-sectional study of Australian postcodes
Type-2 diabetes is a leading cause of death and disability. Emerging evidence suggests that ultraviolet radiation or sun exposure may limit its development. We used freely available online datasets to evaluate the associations between solar radiation and type-2 diabetes prevalence across Australia.
Diabetes (Type 1) Published research Vitamin D and Sunlight Cardiometabolic SunhealthJanuary 2022The Effects of Using the Sun Safe App on Sun Health Knowledge and Behaviors of Young Teenagers: Results of Pilot Intervention Studies
A balanced approach toward sun exposure and protection is needed by young people. Excessive sun exposure increases their risk for skin cancers such as melanoma, whereas some exposure is necessary for vitamin D and healthy bones. We have developed a new iOS smartphone app-Sun Safe-through a co-design process, which aims to support healthy and balanced decision-making by young teenagers (aged 12-13 years).
Published research Vitamin D and Sunlight Human Development and Community Wellbeing Cardiometabolic Sunhealth Subsite: CliniKids Technology & KidsMarch 2022Developing an Online Tool to Promote Safe Sun Behaviors With Young Teenagers as Co-researchers
Despite education about the risks of excessive sun exposure, teenagers in Australia are sun-seeking, with sunburn common in summer. Conversely, some regular (time-limited) exposure to sunlight (that avoids sunburn) is necessary for vitamin D and healthy bones and other molecules important for immune and metabolic health. New interventions are thus required to better support teenagers to make healthy and balanced decisions about their sun behaviors.
Published research Vitamin D and Sunlight Human Development and Community Wellbeing Inflammation Cardiometabolic Sunhealth Subsite: CliniKidsFebruary 2022Sex-Specific Environmental Impacts on Initiation and Progression of Multiple Sclerosis
The immunological mechanisms that contribute to multiple sclerosis (MS) differ between males and females. Females are 2-3 times more likely to develop MS compared to males, however the reason for this discrepancy is unknown. Once MS is established, there is a more inflammatory yet milder form of disease in females whereas males generally suffer from more severe disease and faster progression, neural degradation, and disability.
Published research Pregnancy and Early Life Immunology Inflammation Cardiometabolic SunhealthJanuary 2022Quantifying the effectiveness of betaherpesvirus-vectored transmissible vaccines
Transmissible vaccines have the potential to revolutionize how zoonotic pathogens are controlled within wildlife reservoirs. A key challenge that must be overcome is identifying viral vectors that can rapidly spread immunity through a reservoir population.
Published research Immunisation Infectious Diseases Cardiometabolic SunhealthOctober 2021Risks and Benefits of UV Radiation
While UV radiation is a skin carcinogen, this should not obscure the growing evidence that sunlight has significant health benefits, including impacts on cardiovascular and metabolic health.
Published research Vitamin D and Sunlight Cardiometabolic SunhealthSeptember 2021Sun-health behaviours and attitudes towards sun safety amongst Australian teenagers: a qualitative update
This study aimed to explore current attitudes towards sun protection, and sun-seeking behaviour among young Australian adolescents. It was done as part of a larger project aiming to develop a digital resource to support young people in making informed sun-health decisions.
Published research Vitamin D and Sunlight Human Development and Community Wellbeing Cardiometabolic Sunhealth Youth Mental HealthApril 2021Metabolic dysfunction induced by a high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice
Brown adipose tissue (BAT) may be an important metabolic regulator of whole-body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high-fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPCs)-which give rise to DCs-in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low-dose ultraviolet radiation (UVR) significantly reduced the 'whitening' effect of eating a high-fat diet upon interscapular (i) BAT of mice.
Pregnancy and Early Life Immunology Inflammation Diabetes and ObesityApril 2021Exposomes and metabolic health through a physical activity lens: a narrative review
In this narrative review, we provide an overview of the role of physical activity as part of differing exposomes (our combined non-genetic exposures from conception onwards) and environmental influences on metabolic health. We discuss 'beneficial' exposomes (green/natural outdoor spaces, sun exposure, healthy diets and features of built environments) that could synergise with physical activity to prevent metabolic dysfunction, particularly that related to lifestyle diseases of obesity, type 2 diabetes and metabolic syndrome.
Published research Diabetes and Obesity Respiratory Environmental Health Child Physical Activity, Health and DevelopmentNovember 2020SGLT2 Inhibitor-Induced Sympathoexcitation in White Adipose Tissue: A Novel Mechanism for Beiging
Recent preclinical data show that sodium glucose cotransporter 2 (SGLT2) inhibitors are able to reduce weight gain and induce beiging in white adipose tissue (WAT). We have previously shown that in neurogenic hypertensive Schlager (BPH/2J) mice, treatment with the SGLT2 inhibitor, Dapagliflozin, reduced blood pressure and prevented weight gain. Here we show that chemical sympathetic denervation achieved by systemic administration of 6-hydroxy-dopamine (6-OHDA) reduces body weight and the heightened sympathetic nervous system (SNS) innervation in WAT.
Published research Cardiometabolic Sunhealth Diabetes and ObesityMarch 2020Low-dose UV radiation before running wheel access activates brown adipose tissue
When combined with physical activity, low-dose UVR may more effectively limit adiposity and modulate metabolic and immune pathways in iBAT
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJanuary 2020Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue
Non-burning (low-dose) UVR suppresses the BAT 'whitening', steatotic and pro-diabetic effects of consuming a high-fat diet through skin release of nitric oxide
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJanuary 2020Sun exposure: An environmental preventer of metabolic dysfunction?
Emerging preclinical findings suggest that some sun exposure is necessary for optimal metabolic health
Published research Vitamin D and Sunlight Cardiometabolic SunhealthNovember 2019The challenges of developing and optimising an assay to measure 25-hydroxyvitamin D in saliva
We have developed an LC-MS/MS assay that accurately measures saliva 25(OH)D3 levels, which correlated with serum levels
Published research Vitamin D and Sunlight Inflammation Nutrition in Early Life Cardiometabolic Sunhealth Diabetes and ObesityNovember 2019Associations Between Sun Exposure and Adiposity Were Not Observed in Breast and Prostate Cancer Patients in a Cross-sectional Analysis
There were no statistically significant associations between time spent outdoors and adiposity
Published research Cardiometabolic SunhealthOctober 2019Season, terrestrial ultraviolet radiation, and markers of glucose metabolism in children living in Perth, Western Australia
Increased safe sun exposure in winter therefore represents a plausible means of reducing fasting blood sugar in children with obesity
Published research Cardiometabolic Sunhealth Diabetes and ObesityAugust 2019Systematic Review of the Effects of Ultraviolet Radiation on Markers of Metabolic Dysfunction
Here we review the metabolic effects of exposure to ultraviolet radiation, focusing on the effects of phototherapies
Published research Vitamin D and Sunlight Cardiometabolic SunhealthFebruary 2019Regular exposure to non-burning ultraviolet radiation reduces signs of non-alcoholic fatty liver disease in mature adult mice fed a high fat diet
Frequent exposure to low levels of sunlight may reduce the severity of hepatic steatosis induced in older adults living in environments of high caloric intake
Published research Nutrition Cardiometabolic SunhealthJanuary 2019Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams
While maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring
Published research Cardiometabolic Sunhealth Respiratory Environmental HealthSeptember 2018IFNβ inhibits the development of allergen tolerance and is conducive to the development of asthma on subsequent allergen exposure
Data indicate a role for Interferonβ in linking viral infection and allergy
Asthma Published research Cardiometabolic Sunhealth Cancer Immunology and BiologyJuly 2018High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis
High dose vitamin D supplementation is associated with a shift to a more inflammatory faecal microbiome and increased susceptibility to colitis
Published research Inflammation Cardiometabolic SunhealthApril 2018Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammat roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D. Arch Dermatol Res. 2018;310(3):221-30.
We investigated the ability of topical 1,25(OH)2D to suppress contact dermatitis through an IL9 dependent process, examining mast cells and IL9 secreting cells.
Published research Inflammation Cardiometabolic SunhealthSeptember 2017High-dose intramuscular Vitamin D provides long-lasting moderate increases in serum 25-hydroxVitamin D levels and shorter-Term changes in plasma calcium
Intramuscular injection of a large bolus of Vitamin D effectively increases serum 25-hydroxyVitamin D levels without evidence of metabolic abnormality.
Published research Inflammation Diabetes and ObesitySeptember 2017Clinical, research, and public health implications of poor measurement of Vitamin D status
New initiatives to develop a standard reference method and the assignment of "true" values to samples provide a solution to these problems.
Published research Vitamin D and Sunlight Diabetes and ObesityAugust 2017Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity
In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset.
Published research Inflammation Cardiometabolic Sunhealth Airway Epithelial Research P4 Respiratory Health for Kids Respiratory Environmental HealthApril 2017Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice
Exposure to sunlight may limit cardiometabolic risk.
Published research Inflammation Cardiometabolic Sunhealth Diabetes and ObesityMarch 2017Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes
Emerging findings suggest a protective role for ultraviolet radiation (UVR) and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.
Diabetes (Type 1) Published research Inflammation Diabetes and ObesityNovember 2016A pathogenic role for the integrin CD103 in experimental allergic airways disease
Role for CD103 in the pathogenesis of experimental allergic airways disease in BALB/c mice through local control of CD4+ T cell and DC subset recruitment
Published research Pregnancy and Early Life Immunology Cardiometabolic SunhealthOctober 2016Sun exposure and its effects on human health: Mechanisms through which sun exposure could reduce the risk of developing obesity and cardiometabolic dysfunction
The cardiometabolic protective effects of ultraviolet radiation and mechanistic pathways through which ultraviolet radiation could be beneficial.
Published research Vitamin D and Sunlight Cardiometabolic SunhealthSeptember 2016Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner
Maintaining sufficient vitamin D is necessary for optimal lung health, and vitamin D may modulate the lung microbiome in a sex-specific fashion
Published research Academic Biostatistics Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthSeptember 2016Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation
Dietary vitamin D3 increased the suppressive activity of regulatory T cells in the skin-draining lymph nodes, which are poised to suppress dermal inflammation
Published research Vitamin D and Sunlight Inflammation Cardiometabolic Sunhealth Cancer Immunology and BiologySeptember 2016Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease
Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function
Asthma Published research Inflammation Systems Immunology Cardiometabolic Sunhealth Airway Epithelial ResearchMay 2015Can skin exposure to sunlight prevent liver inflammation?
Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD.
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthMarch 2015The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function
In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function.
Published research Vitamin D and Sunlight Inflammation Systems Immunology Cardiometabolic SunhealthFebruary 2015Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function
Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D...
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJanuary 2015Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation.
During respiratory inflammation, it is generally assumed that dendritic cells differentiating from the bone marrow are immunogenic rather than immunoregulatory.
Published research Inflammation Cardiometabolic SunhealthDecember 2014Vitamin D and immunity
The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed,...
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthNovember 2014Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D
UVR or sunlight exposure may be an effective means of suppressing the development of obesity and MetS, through mechanisms that are independent of vitamin D
Published research Vitamin D and Sunlight Inflammation Brain Tumour Research Cardiometabolic SunhealthApril 2014Vitamin D status and ill health
This paper is a comment in response to a review of Vitamin D status and its association with ill health.
Published research Vitamin D and Sunlight Cardiometabolic SunhealthMarch 2014Vitamin D deficiency causes airway hyperresponsiveness and increases airway smooth muscle mass in the lungs of female BALB/c mice
We tested whether there is a causal association between vitamin D deficiency, airway smooth muscle (ASM) mass, and the development of airway hyperresponsiveness
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthMarch 2014Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms
Pregnancy is a time of vulnerability for vitamin D insufficiency, and there is an emerging literature associating low levels of 25(OH)-vitamin D with...
Published research Autism Research Inflammation Human Immunology Cardiometabolic SunhealthJuly 2013Characterization of regulatory dendritic cells differentiated from the bone marrow of UV-irradiated mice
In summary, UV-BMDCs do not express the classical phenotypic or gene expression properties of DCs reported by others as 'regulatory' or 'tolerogenic'.
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJune 2013Reversible Control by Vitamin D of Granulocytes and Bacteria in the Lungs of Mice: An Ovalbumin-Induced Model of Allergic Airway Disease
Vitamin D may be essential for restricting the development and severity of allergic diseases and asthma, but a direct causal link between vitamin D...
Asthma Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJune 2013Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice
To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established.
Published research Pregnancy and Early Life Immunology Inflammation Cardiometabolic Sunhealth Cancer Immunology and BiologyApril 2013Exposure to UV Wavelengths in Sunlight Suppresses Immunity. To What Extent is UV-induced Vitamin D3 the Mediator Responsible?
In experimental models, both vitamin D3-dependent and vitamin D3-independent pathways have been implicated in the mechanisms of UVR-induced systemic...
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthFebruary 2013Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in the bone marrow
Injection of BM-differentiated DCs from nonchimeric mice restored the reduced immune responses of PGE2-chimeric mice.
Published research Inflammation Cardiometabolic Sunhealth Cancer Immunology and BiologyJanuary 2013Optimized 25-hydroxyvitamin D analysis using liquid-liquid extraction with 2D separation with LC/MS/MS detection, provides superior precision
The analysis of 25-hydroxyvitamin D3 (25(OH)D3) and related metabolites represents a considerable challenge for both clinical and research laboratories...
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJanuary 2013Immune modulation by UV: Role of vitamin D
In this chapter, evidence for and evidence against the involvement of vitamin D in the immunoregulatory properties of UV radiation is presented.
Asthma Diabetes (Type 1) Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthNovember 2012The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation
Ultraviolet radiation (UVR) from sunlight is immunomodulatory and the main source of vitamin D for humans.
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthSeptember 2012Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence
Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator.
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthAugust 2012Toward homeostasis: Regulatory dendritic cells from the bone marrow of mice with inflammation
Inflammatory mediators from peripheral tissues may control dendritic cell (DC) development in the bone marrow.
Published research Pregnancy and Early Life Immunology Inflammation Cardiometabolic SunhealthFebruary 2012Vitamin D 3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease
In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma.
Asthma Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthDecember 2011Differences in control by UV radiation of inflammatory airways disease in naïve and allergen pre-sensitised mice
Exposure of skin to UV radiation (UVR) prior to allergen exposure can inhibit inflammatory airways disease in mice by reducing effector CD4+ T cells in both...
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthAugust 2011Modulation of the immune system by UV radiation: More than just the effects of vitamin D?
Humans obtain most of their vitamin D through the exposure of skin to sunlight
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthFebruary 2011Vitamin D deficiency causes deficits in lung function and alters lung structure
The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease
Asthma Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJanuary 2011Immune mechanisms by which topically applied vitamin D acts as a therapeutic agent
Vitamin D, nutrition, diet, therapeutic agent
Published research Nutrition Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthDecember 2010Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+
Direct UV irradiation of dendritic cells and Langerhans cells reduces their Ag presenting ability. However, the effects of UV on CD11c(+) cells located...
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthNovember 2010Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells
The active form of vitamin D, 1,25-hydroxyvitamin D(3) [1,25(OH)(2)D(3)] is produced in skin following exposure to sunlight
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthOctober 2010Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2
Vitamin D may be responsible for reducing the development and severity of autoimmune and allergic diseases. Topically applied 1,25-dihydroxyvitamin D(3) (1,25(O
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJuly 2010Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells
Topical creams containing the active form of vitamin D (1,25-dihydroxyvitamin D3; 1,25(OH)2D3) or analogues of this compound are currently used with some succes
Published research Vitamin D and Sunlight Inflammation Cardiometabolic SunhealthJune 20101,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses
The severity of allergic diseases may be modified by vitamin D. However, the immune pathways modulated by the active form of vitamin D, 1,25-dihydroxyvitamin D.
Asthma Published research InflammationApril 2010UV exposure and protection against allergic airways disease
Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity.
Asthma Published research Vitamin D and Sunlight Pregnancy and Early Life Immunology Inflammation Cardiometabolic Sunhealth -
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