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        A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxin

        Suggests that IL-1R1 expression provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection. ...

        Research

        T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

        To show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy. ...

        Research

        The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood

        This study examined whether maternal and/or fetal folate status in pregnancy is associated with infant allergic outcomes. ...

        Research

        The effects of maternal smoking on early mucosal immunity and sensitization at 12 months of age

        In this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization... ...

        Research

        World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics

        Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20-30% in those with an allergic... ...

        Research

        High-Rise Apartments and Urban Mental Health—Historical and Contemporary Views

        High-rise apartment buildings have long been associated with the poor mental health of their residents ...

        Research

        Analytical bias in the measurement of plasma 25-hydroxyvitamin D concentrations in infants

        To our knowledge, this is the first study to show that the reported 25(OH)D concentration may be influenced by both age and assay type ...

        Research

        Histone modifications and their role in epigenetics of atopy and allergic diseases

        This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases ...

        Research

        World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin D

        Vitamin D is involved in the regulation of the immune system and it may play a role in the development, severity and course of asthma and other allergic... ...

        Research

        Natural environments, nature relatedness and the ecological theater: connecting satellites and sequencing to shinrin-yoku

        Mechanisms-including aerobiological and epigenetic-that might help explain some of the noted positive health outcomes ...

        Research

        Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

        Study the innate immune function in ulcerative colitis patients who fail to respond to anti-tumor necrosis factor therapy ...

        Research

        Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

        With emerging research involving green space, the microbiome, biodiversity and positive psychology, we discuss ecological justice in the dysbiosphere ...

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