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        Research Note: Adaptive trials

        This Research Note has explored the strengths, risks and potential complexity of adaptive trials ...

        Research

        Links2HealthierBubs' cohort study: Protocol for a study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women

        Multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions ...

        Research

        Patient-reported outcome measures for paediatric acute lower respiratory infection studies

        Patient-reported outcome measures (PROMs) are recommended for capturing meaningful outcomes in clinical trials. The use of PROMs for children with acute lower respiratory infections (ALRIs) has not been systematically reported. We aimed to identify and characterise patient-reported outcomes and PROMs used in paediatric ALRI studies and summarise their measurement properties. ...

        Research

        Pertussis immunisation in infancy and atopic outcomes: A protocol for a population-based cohort study using linked administrative data

        The burden of IgE-mediated food allergy in Australian born children is reported to be among the highest globally. This illness shares risk factors and frequently coexists with asthma, one of the most common noncommunicable diseases of childhood. ...

        Research

        Status epilepticus outcomes among vaccinated and unvaccinated children: A population-based study

        To determine the proportion of first status epilepticus cases that are vaccine-proximate and compare clinical outcomes to non-vaccine-proximate cases. ...

        Research

        Effectiveness of pneumococcal conjugate vaccine against hospital admissions for pneumonia in Australian children

        Reductions in pneumonia-coded hospital admissions in unvaccinated children predominated in non-Aboriginal children with low incidence of pneumonia ...

        Research

        Timeliness of signal detection for adverse events following influenza vaccination in young children: a simulation case study

        Active vaccine safety surveillance leading to rapid detection of a safety signal would likely have resulted in earlier suspension of Fluvax from the vaccination programme ...

        Research

        Birth outcomes in Aboriginal mother–infant pairs from the Northern Territory, Australia, who received 23-valent polysaccharide pneumococcal vaccination during pregnancy

        We found a numerically higher rate of preterm births among women who received 23vPPV in pregnancy compared to unvaccinated pregnant women ...

        Research

        RD-RAP: Beyond rare disease patient registries, devising a comprehensive data and analytic framework

        We introduce and describe the concept of a Rare Disease Registry and Analytics Platform ...

        Research

        FeBRILe3 Project: protocol for a prospective study and safety evaluation assessing Fever, Blood cultures and Readiness for discharge in Infants Less than 3 months old

        Assess the safety and impact of the introduction of a guideline recommending early discharge of infants with fever without source at low risk of serious bacterial infection ...

        Research

        Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: A case-control study protocol

        We aim to determine the contribute of bacteria and virus to childhood CAP to inform further development of effective strategies. ...

        Research

        Probabilistic linkage of national immunisation and state-based health records for a cohort of 1.9 million births to evaluate Australia’s childhood immunisation program

        To describe the process for assembling a linked study that will enable the conduct of population-based studies related to immunisation and immunisation policy. ...

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