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        Environmental Factors in Children's Asthma and Respiratory Effects

        Childhood asthma is a condition characterized by airflow obstruction that varies in time spontaneously, in response to various environmental stimuli... ...

        Research

        Mannitol challenge testing for asthma in a community cohort of young adults

        We aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort. ...

        Research

        Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions

        One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern... ...

        Research

        Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohorts

        Our findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important... ...

        Research

        Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages

        Human peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-gamma... ...

        Research

        Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma

        No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence... ...

        Research

        Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents

        Using prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin... ...

        Research

        Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone mass

        There are moderate associations between vitamin D status measured in prepuberty, adolescence, and early adulthood ...

        Research

        Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

        Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure ...

        Research

        A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood

        Neonatal dendritic cells generated form CD34+ cord blood progenitors have a higher inflammatory potential when exposed to viral than bacterial related stimuli ...

        Research

        Oestrogen amplifies pre-existing atopy-associated Th2 bias in an experimental asthma model

        The role of oestrogen in experimental atopic asthma, and guide future research on sex-related variations in atopic asthma susceptibility/intensity ...

        Research

        Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

        GWAS analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis suggested shared genetic mechanisms across rhinitis-related traits ...

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