We aimed to measure the antibody development to 2 bacteria in a birth cohort at high risk of allergic disease, and to assess which responses are asthma-linked. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• April 2012

AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

Chronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• August 2011

Airway epithelial cells act through multiple mechanisms to function as an important component of the pulmonary defence strategy that is crucial... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• December 2010

To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

The co-exposure responses in the Th2high BN incorporated type I interferon/Th1, alternative macrophage activation/Th2 and Th17 signatures ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

Early immunological influences on asthma development: opportunities for early intervention ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

In asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition systems; the interaction with allergen exposure; the additional involvement of host gut and airway microbiota; the role of viral respiratory infections in interaction with the 17q21 and CDHR3 genetic loci; and the importance of in utero and early-life timing of exposures. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

We aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• February 2017

Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolescents conceived without? ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022