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        Multi-centre, multi-disciplinary study using a systems biology approach to investigate immunomodulation in children with acute wheeze

        Ingrid Pat Laing Holt IL PG BSc PhD PhD, DSc, FRCPath, FRCPI, FAA Honorary Research Fellow Emeritus Honorary Researcher 6319 1828 Ingrid.laing@telethonkids.org.au@hotmail.cmo Patrick.Holt@telethonkids.org.au Honorary Research Fellow Emeritus ...

        Research

        The mechanism of deep inspiration-induced bronchoprotection: Evidence from a mouse model

        In healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed... ...

        Research

        Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

        We aimed to measure the antibody development to 2 bacteria in a birth cohort at high risk of allergic disease, and to assess which responses are asthma-linked. ...

        Research

        Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma

        The objective of this study was to examine the influence of viral respiratory infection (VRI) on treatment response in acute asthma in children. ...

        Research

        Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific

        Chronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear ...

        Research

        Bronchial brushings for investigating airway inflammation and remodelling

        Asthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable... ...

        Research

        Neonatal immune function and inflammatory illnesses in later life: lessons to be learnt from the developing world?

        With the emergence of allergic and autoimmune diseases in populations that have started to transit to a western lifestyle, there has been an increasing... ...

        Research

        House dust mite allergens in asthma and allergy

        IgE antibodies in house dust mite (HDM) allergy follow a predictable pattern. Half are directed against two dominant allergens and the remainder largely against ...

        Research

        Early immunological influences on asthma development: opportunities for early intervention

        Early immunological influences on asthma development: opportunities for early intervention ...

        Research

        Investigations into the role of ST2 in acute asthma in children

        This study investigated the potential role of ST2 in children with acute asthma. ...

        Research

        Acute viral bronchiolitis in infants and young children

        Deborah Pat Strickland Holt DH PG PhD PhD, DSc, FRCPath, FRCPI, FAA Program Head, Immunobiology and Immunotherapeutic Program Emeritus Honorary Researcher Deb.Strickland@telethonkids.org.au Patrick.Holt@telethonkids.org.au Program Head, ...

        Research

        Pulmonary delivery of virosome-bound antigen enhances antigen-specific CD4+ T cell proliferation compared to liposome-bound or soluble antigen

        Pulmonary administration of biomimetic nanoparticles loaded with antigen may represent an effective strategy to directly modulate adaptive immune responses ...

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