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        Directing the future breakthroughs in immunotherapy: The importance of a holistic approach to the tumour microenvironment

        Immunotherapy has revolutionised the treatment of cancers by exploiting the immune system to eliminate tumour cells. Despite the impressive response in a proportion of patients, clinical benefit has been limited thus far. ...

        Research

        PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

        Our findings define PTPN2 as a target for bolstering T-cell-mediated anti-tumour immunity and CAR T-cell therapy against solid tumours. ...

        Research

        Acquired resistance during adoptive cell therapy by transcriptional silencing of immunogenic antigens

        These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control ...

        Research

        Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

        Our results show that TRM cells have a fundamental role in the surveillance of subclinical melanomas in the skin by maintaining cancer-immune equilibrium ...

        Research

        Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

        These findings implicate the activation of STAT3 as one pathway that may mediate resistance to IGF-II-targeted therapy in HCC ...

        Research

        Immunogenicity and safety of single-dose, 13-valent pneumococcal conjugate vaccine in pediatric and adolescent oncology patients

        All children who are receiving therapy for cancer should receive a single dose of PCV13 as soon as possible after diagnosis, regardless of prior PCV exposure. ...

        Research

        Asymptomatic CMV infections in long-term renal transplant recipients are associated with the loss of FcRγ from LIR-1+ NK cells

        CMV can be reactivated in symptom-free renal transplant recipients, affecting the phenotypic, and functional profiles of NK cells ...

        Research

        Mixed Proteasomes Function To Increase Viral Peptide Diversity and Broaden Antiviral CD8+ T Cell Responses

        Many proteasomes expressed by normal cells and cells exposed to cytokines are "mixed", that is, contain both standard and immunoproteasome subunits. ...

        Research

        Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice

        To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established. ...

        Research

        Developing new immune based therapies for neuroblastoma

        Alison Linda W. Joost Omar McDonnell Wijaya Lesterhuis Elaskalani AM LW WJL OE BSc (Hons), PhD BSc PhD BSc, MSc, PhD Early Career Fellow Postdoctoral Researcher Program Head, Cancer / Chronic and Severe Diseases RFA Deputy Head Senior Research ...

        Research

        Resident CD8+ and Migratory CD103+ Dendritic Cells Control CD8 T Cell Immunity during Acute Influenza Infection

        The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and... ...

        Research

        Radiomics-A new age of presurgical assessment to improve outcomes in pediatric neuro-oncology

        Citation: Valvi S, Hansford JR. Radiomics-A new age of presurgical assessment to improve outcomes in pediatric neuro-oncology. Neuro Oncol. 2022;24(6):995-6. Keywords: Ependymoma; neurology ...

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