Malignant central nervous system (CNS) cancers are among the most difficult to treat, with low rates of survival and a high likelihood of recurrence. This is primarily due to their location within the CNS, hindering adequate drug delivery and tumour access via surgery. Furthermore, CNS cancer cells are highly plastic, an adaptive property that enables them to bypass targeted treatment strategies and develop drug resistance. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

These findings reveal a central role of the DG receptor, not only as a structural element, but also as a critical factor promoting mesenchymal-like GBM ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Results support the emerging concept that CD103+ CD8+ tissue‐resident memory T cells are key mediators of cancer surveillance ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Our findings provide insight into the immune cell populations important for maintaining long-term tumour dormancy in peripheral tissues ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes. To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the disease and the impact of current therapies are limited. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the role of individual subtypes remains unclear. Here we systematically compared the capacity of distinct type I IFN subtypes to enhance T cell responses to a whole-cell vaccination strategy in a pre-clinical murine model. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Cross-presenting dendritic cells (DC) offer an attractive target for vaccination due to their unique ability to process exogenous antigens for presentation on MHC class I molecules. Recent reports have established that these DC express unique surface receptors and play a critical role in the initiation of anti-tumor immunity, opening the way for the development of vaccination strategies specifically targeting these cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021

We present a curated panel of 12 readily-usable, cell lines representing the spectrum of molecular subtypes of IDH-wildtype glioblastoma ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

In response to DNA damaging chemotherapy, targeting MK2 in p53-mutated cells produces a phenotype that is distinct from the p53-deficient phenotype ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

Despite low ERBB4 mRNA in glioblastoma, the functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

Influenza A virus (IAV) is a dangerous virus equipped with the potential to evoke widespread pandemic disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• November 2013