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        Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in the bone marrow

        Injection of BM-differentiated DCs from nonchimeric mice restored the reduced immune responses of PGE2-chimeric mice. ...

        Research

        The Immune Response to Skin Trauma Is Dependent on the Etiology of Injury in a Mouse Model of Burn and Excision.

        This article investigates the impact of burn & excisional injury on the immune system. ...

        Research

        T cells recognizing a 11mer influenza peptide complexed to H-2D b show promiscuity for peptide length

        T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. ...

        Research

        Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103− and XCR1+CD103+ dendritic cells

        This report provides new insight into the functional specialization within the broad network of dendritic cells that are responsible for skin immunosurveillance ...

        Research

        Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies

        Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear. ...

        Research

        Editorial: Insights Into Biomarkers, Cytokines, and Chemokines in Skin Cancer

        Our current Research Topic highlights the complexity of the relationship between the skin, immune system and skin cancer ...

        Research

        Dendritic cells and cancer: From biology to therapeutic intervention

        In this review, we discuss the different subsets of tumor-infiltrating dendritic cells and their role in anti-tumor immunity ...

        Research

        CD8+XCR1neg Dendritic Cells Express High Levels of Toll-Like Receptor 5 and a Unique Complement of Endocytic Receptors

        Our data demonstrate that CD8+XCR1neg DCs possess a unique pattern of endocytic receptors and a restricted TLR profile that is particularly enriched for TLR5 ...

        Research

        IFNβ inhibits the development of allergen tolerance and is conducive to the development of asthma on subsequent allergen exposure

        Data indicate a role for Interferonβ in linking viral infection and allergy ...

        Research

        Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors

        Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

        Research

        Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks

        The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes. ...

        Research

        Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

        Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

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