While maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

In this study, we aimed to use microRNAs-which are critical regulators of signaling cascades-to identify so far uncharacterized asthma pathogenesis pathways ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

This study tested the utility of optical coherence tomography-based indentation to assess mechanical properties of respiratory tissues in disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

Electronic cigarettes (e-cigarettes) are often perceived to be safer than smoking, which has led to some women switching to e-cigarettes during pregnancy. However, the effects of switching from smoking to e-cigarettes on both pregnancy outcomes and the foetus are largely unknown. This study aimed to investigate the effects of switching from tobacco smoking to e-cigarette use in very early pregnancy on birth outcomes, neurodevelopment and behaviour of the offspring. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Prenatal alcohol exposure is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA methylation in offspring cells and tissues, providing evidence for a potential mechanistic link to Fetal Alcohol Spectrum Disorder. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

• 1. Telethon Kids Institute
• Projects

We propose that mechanical abnormalities of the airway wall acquired through disrupted fetal growth impact susceptibility to disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

Mineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• February 2014

This work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Exposure to diesel exhaust particles (DEP) is thought to exacerbate many pre-existing respiratory diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012