We investigated whether cyanide in bronchoalveolar lavage (BAL) fluid could be used as an early diagnostic biomarker of infection in kids with cystic fibrosis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• March 2011

There is controversy regarding whether cystic fibrosis (CF) airway epithelial cells (AECs) are intrinsically proinflammatory. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

This study investigated the nature and prevalence of atypical pain responses in Rett syndrome and their relationships with specific MECP2 mutations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

For cystic fibrosis (CF) patients older than 6 years there are convincing data that suggest respiratory tract exacerbations (RTE) play an important role in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

To investigate changes in trapped air volume and distribution over time and compare computed tomography (CT) with pulmonary function tests for determining... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• March 2015

We hypothesized that allergic inflammation decreases the level of circulating 25(OH)D and tested this using a mice model of house dust mite (HDM) induced... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

The present study investigated whether lung function measured by forced oscillation technique would be impaired in the presence of infection,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• September 2015

Cystic Fibrosis (CF) is a genetic condition characterized by neutrophilic inflammation and recurrent infection of the airways. How these processes are initiated and perpetuated in CF remains largely unknown. We have demonstrated a link between the intestinal microbiota-related metabolites bile acids and inflammation in the bronchoalveolar lavage fluid from children with stable CF lung disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

For those born with cystic fibrosis (CF), hyper-concentrated mucus with a dysfunctional structure significantly impacts CF airways, providing a perfect environment for bacterial colonization and subsequent chronic infection. Early treatment with antibiotics limits the prevalence of bacterial pathogens but permanently alters the CF airway microenvironment, resulting in antibiotic resistance and other long-term consequences. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women who were stratified into high and low alignment to a MD throughout pregnancy and investigate the relationship of the diet to inflammatory markers.   ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

The global human population is still growing such that our collective enterprise is driving environmental catastrophe. Despite a decline in average population growth rate, we are still experiencing the highest annual increase of global human population size in the history of our species-averaging an additional 84 million people per year since 1990. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• March 2024