To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration.. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

Jenefer Timo Carol Sarra Helen Vanessa Blackwell Lassmann Bower Jamieson Leonard Fear JM T C SE HM VF BSc with First Class Honours, PhD, DSc, FMedSci, FAA BSc (Hons) MSc PhD MBBS MSc PhD FAFPHM DLSHTM FPHA BSc (Hons) MSc PhD MBChB MPH BSc (Hons), ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Genetics and Health

Sarra Timo Christopher Lea-Ann Ruth Deborah Jamieson Lassmann Blyth Kirkham Thornton Lehmann SE T CC LK RT D BSc (Hons) MSc PhD BSc (Hons) MSc PhD MBBS (Hons) DCH FRACP FRCPA PhD PhD PhD AO, MBBS, MSc Senior Research Fellow Feilman Fellow; Program ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Genetics and Health

Our goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese immigrants, which fails to prime the immune system. Here, we investigated how differences in composition of oropharyngeal microbiome may contribute to patterns of interaction between the microbiome and immune system in Chinese immigrants living in Australia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Our results show perturbation of host mitochondrial function following T. gondii infection that likely impacts on pathogenesis of disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• December 2017

Here we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

Our data provide insight into the molecular mechanisms underpinning the association of HLA-DRB1 alleles with risk versus protection in visceral leishmaniasis in humans ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• April 2018

We found no increased risk of poor development among boys with hypospadias or undescended testis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

We believe this data represents a useful resource to understand the central nervous system in macaque. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• March 2017

GWAS results provide firm confirmation for the importance of antigen presentation and the regulation of IFNγ in determining the outcome of Leishmania infections ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020