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        Analysis of expression of FLI1 and MMP1 in American cutaneous leishmaniasis caused by Leishmania braziliensis infection

        MMP1 is regulated by factors other than FLI1, and that the influence of IL-6 on MMP1 was independent of its effect on FLI1 in Leishmania braziliensis ...

        Research

        Epigenetic dysregulation of host gene expression in Toxoplasma infection with specific reference to dopamine and amyloid pathways

        Our results provide a possible functional link between Toxoplasma gondii infection and congenital/early life and adult neurological clinical signs ...

        Research

        Does otitis media in early childhood affect later behavioural development? Results from the Western Australian Pregnancy Cohort (Raine) Study

        The relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders. ...

        Research

        Meta-taxonomic analysis of prokaryotic and eukaryotic gut flora in stool samples from visceral leishmaniasis cases and endemic controls in Bihar State India

        We evaluate a meta-taxonomic approach to determine the composition of prokaryotic and eukaryotic gut microflora using sequencing of 16S RNA and 18S rRNA ...

        Research

        Personalised analytics for rare disease diagnostics

        Here we focus on the problem of prioritising variants with respect to the observed disease phenotype ...

        Research

        A comparative molecular and 3-dimensional structural investigation into cross-continental and novel avian Trypanosoma spp. in Australia

        Here, we confirm four intercontinental species of avian trypanosomes in native Australian birds, and identify a new avian Trypanosoma. ...

        Research

        Confirmation of childhood acute lymphoblastic leukemia Variants, ARID5B and IKZF1, and interaction with parental environmental exposures

        The polygenic nature of childhood ALL predisposition together with the timing of environmental triggers may hold vital clues for disease etiology. ...

        Research

        Genetic and functional evidence for a role for SLC11A1 in susceptibility to otitis media in early childhood in a Western Australian population

        Otitis media (OM) is a common disease in early childhood characterised by inflammation of the middle ear. ...

        Research

        Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis

        We assessed 30 sibships and 89 parent/case trios of presumed ocular toxoplasmosis (POT) to evaluate associations with polymorphisms in the NOD2 gene. ...

        Research

        Cytokine responses to novel antigens in a peri-urban population in Brazil exposed to Leishmania infantum chagasi

        Visceral leishmaniasis (VL) is fatal if untreated, and there are no vaccines for this disease ...

        Research

        Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood

        We identified several novel candidate genes which warrant further analysis in cohorts matched more precisely for clinical phenotypes. ...

        Research

        A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

        To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis... ...

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