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        OPTIMUM: OPTimising IMmunisation Using Mixed schedules

        Pat Peter Susan Tom Jennifer Holt Richmond Prescott Snelling Kent PG PC SL T J PhD, DSc, FRCPath, FRCPI, FAA MBBS MRCP(UK) FRACP MBBS BMedSci PhD FRACP BMBS DTMH GDipClinEpid PhD FRACP RN Emeritus Honorary Researcher Head, Vaccine Trials Group ...

        Research

        A Phase 3, randomized, double-blind trial to evaluate the safety and immunogenicity of a 20-valent pneumococcal conjugate vaccine given as a series of 2 infant doses and 1 toddler dose in healthy infants (NeXXstep)

        Jennifer Peter Kent Richmond J PC RN MBBS MRCP(UK) FRACP Clinical Research Manager Head, Vaccine Trials Group Jennifer.Kent@telethonkids.org.au Clinical Research Manager Head, Vaccine Trials Group Jennifer completed her Diploma of Nursing in 1986 at ...

        Research

        Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial

        Viral respiratory infections are associated with significant morbidity and mortality. ...

        Research

        Use of data linkage to investigate the aetiology of acute lower respiratory infection hospitalisations in children

        The aim was to document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children ...

        Research

        Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine

        Successful defence against viral pathogens requires the rapid recognition of virus-specific "danger signals" and the activation of both innate and adaptive... ...

        Research

        Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus

        Group B streptococcus (GBS) is an important cause of early- and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility... ...

        Research

        Maternal, umbilical cord and neonatal inflammatory and hematologic markers in histologic chorioamnionitis

        Maternal, umbilical cord, neonatal inflammatory, hematologic markers, histologic chorioamnionitis... ...

        Research

        Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis

        In vitro investigations of human innate immune responses to extracellular bacteria commonly utilise killed preparations in preference to live organisms ...

        Research

        The changing epidemiology of invasive pneumococcal disease

        We investigated trends in invasive pneumococcal disease (IPD) in Western Australia (WA). ...

        Research

        TLR2 mediates recognition of live staphylococus epidermidis

        Staphylococcus epidermidis is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age ...

        Research

        Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections

        This review aims to systematically identify and summarise the effects of different antifungal therapies in children with proven, probable or suspected... ...

        Research

        Diverging trends for lower respiratory infections in non-Aboriginal and Aboriginal children

        To investigate temporal trends in admission rates for acute lower respiratory infections (ALRI) in a total population birth cohort of non-Aboriginal and... ...

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