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        Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection

        IRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections in HBE cells ...

        Research

        Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

        Differential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets ...

        Research

        Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection

        Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens. ...

        Research

        Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects

        Mononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells ...

        Research

        A genomics-based approach to assessment of vaccine safety and immunogenicity in children

        This methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a... ...

        Research

        Asthma: Acute asthma flare-up in school-age children

        Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

        Research

        Bilateral murine tumor models for characterizing the response to immune checkpoint blockade

        This protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade ...

        Research

        Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles

        the association between infant LRTI and risk for persistent wheeze/asthma in this cohort is generally stronger for fLRTIs than for other infection categories ...

        Research

        Respiratory viral infections and host responses; insights from genomics

        Review of the viral sensing pathways and organizing principles that govern the innate immune response to infection ...

        Research

        Distinguishing benign from pathologic TH2 immunity in atopic children

        In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor ...

        Research

        Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

        The objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo. ...

        Research

        Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

        The objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo. ...

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