Asthma exacerbations are heterogeneous conditions that involve the complex interplay between environmental exposures and innate and adaptive immune function ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• March 2015

In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• February 2013

Caroline Glenn Jonathan Michael Pat Tim Tobias Motteram Pearson Carapetis AM Serralha Holt Barnett Kollmann CM G JR MS PG TB TK BHlthSc&BCom(Hon), MClinEmbryol BA (Education) PhD Candidate AM MBBS FRACP FAFPHM PhD FAHMS PhD, DSc, FRCPath, FRCPI, FAA ...

• 1. Telethon Kids Institute
• Projects

Anya Deborah Pat Jones Strickland Holt AJ DH PG BSc MSc PhD PhD PhD, DSc, FRCPath, FRCPI, FAA Honorary Research Associate Program Head, Immunobiology and Immunotherapeutic Program Emeritus Honorary Researcher anya.jones@telethonkids.org.au ...

• 1. Telethon Kids Institute
• Projects

Human rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during these exacerbations are heterogeneous and are characterized by the presence or absence of robust interferon responses. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021

T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Here, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• December 2018

CFTR-dependent imbalance of macrophage phenotypes and functions could contribute to the exaggerated inflammatory response seen in CF lung disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• July 2017

HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016