This study identified that expsoure to folate has effects on the regulation of DNA methylation during fetal development. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• June 2014

Nanoparticles are being developed for diverse biomedical applications, but there is concern about potential to promote inflammation, particularly in the lungs. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010

This chapter describes the preparation of respiratory tract tissue from both mice and rats for the isolation of respiratory tract dendritic cells (RTDC). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

The respiratory tract is an attractive target organ for novel diagnostic and therapeutic applications with nano-sized carriers, but their immune effects and... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

Inflammatory mediators from peripheral tissues may control dendritic cell (DC) development in the bone marrow. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• August 2012

In this review, we discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

This protocol adapted an experimental animal model of disease for sensitization to ovalbumin during the immediate post-weaning period beginning at 21 days of age ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018