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        Research

        Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell tolerance

        Concerns about the risk of inducing immune deviation-associated "neonatal tolerance" as described in mice have restricted the widespread adoption... ...

        Research

        Unlocking immune-mediated disease mechanisms with transcriptomics

        The transcriptome represents the entire set of RNA transcripts expressed in a cell, reflecting both the underlying genetic and epigenetic landscape and environmental influences, providing a comprehensive view of functional cellular states at any given time. Recent technological advances now enable the study of the transcriptome at the resolution of individual cells, providing exciting opportunities to characterise cellular and molecular events that underpin immune-medicated diseases. ...

        Research

        Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

        Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function ...

        Research

        Innate immune activation occurs in acute food protein–induced enterocolitis syndrome reactions

        Food reactions in food protein–induced enterocolitis syndrome are predominantly underpinned by activation of the innate immune system ...

        Research

        Protection against maternal infection-associated fetal growth restriction: Proof-of-concept with a microbial-derived immunomodulator

        This study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal ...

        Research

        Searching for a technology-driven acute rheumatic fever test: the START study protocol

        The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus. ...

        Research

        Small nucleolar RNA networks are up-regulated during human anaphylaxis

        Anaphylaxis is a severe, potentially life-threatening allergic reaction driven primarily by the activation of mast cells. We still fail to understand factors underlying reaction severity. Furthermore, there is currently no reliable diagnostic test to confirm anaphylaxis in the emergency department. ...

        Research

        Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

        Cancer immunotherapy has shown impressive results, but most patients do not respond. ...

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