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        Research

        Respiratory viral infections and host responses; insights from genomics

        Review of the viral sensing pathways and organizing principles that govern the innate immune response to infection ...

        Research

        Asthma: Acute asthma flare-up in school-age children

        Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic ...

        Research

        Directing the future breakthroughs in immunotherapy: The importance of a holistic approach to the tumour microenvironment

        Immunotherapy has revolutionised the treatment of cancers by exploiting the immune system to eliminate tumour cells. Despite the impressive response in a proportion of patients, clinical benefit has been limited thus far. ...

        Research

        Airway IRF7hi versus IRF7lo molecular response patterns determine clinical phenotypes in children with acute wheezing

        We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children. ...

        Research

        QuantSeq. 3′ Sequencing combined with Salmon provides a fast, reliable approach for high throughput RNA expression analysis

        QuantSeq, coupled with a fast quantification method such as Salmon, should provide a viable alternative to traditional RNA-Seq in many applications ...

        Research

        Distinguishing benign from pathologic TH2 immunity in atopic children

        In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor ...

        Research

        Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

        Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained ...

        Research

        Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

        The objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo. ...

        Research

        Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

        The objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo. ...

        People

        Michael Serralha

        Michael Serralha MS Research Assistant michael.serralha@telethonkids.org.au Michael Serralha was born and raised in Cape Town. After high school he ...

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