T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells. ...

• 1. Telethon Kids Institute
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• 2021
• July 2021

Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations ...

• 1. Telethon Kids Institute
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• 2018
• November 2018

Here, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases ...

• 1. Telethon Kids Institute
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• 2018
• December 2018

HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

• 1. Telethon Kids Institute
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• 2016
• October 2016

Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens. ...

• 1. Telethon Kids Institute
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• 2014
• January 2014

Honorary Research Associate ...

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the association between infant LRTI and risk for persistent wheeze/asthma in this cohort is generally stronger for fLRTIs than for other infection categories ...

• 1. Telethon Kids Institute
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• 2019
• November 2019

This protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade ...

• 1. Telethon Kids Institute
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• 2020
• May 2020

Mononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells ...

• 1. Telethon Kids Institute
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• 2016
• February 2016

Review of the viral sensing pathways and organizing principles that govern the innate immune response to infection ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2016
• November 2016