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        Research

        Mannitol challenge testing for asthma in a community cohort of young adults

        We aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort. ...

        Research

        Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages

        Human peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-gamma... ...

        Research

        Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohorts

        Our findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important... ...

        Research

        Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents

        Using prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin... ...

        Research

        Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma

        No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence... ...

        Research

        Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions

        One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern... ...

        Research

        Virus infection and allergy in the development of asthma: What is the connection?

        Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy. ...

        Research

        Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development

        The objective was to determine the association between maternal serum 25(OH)-vitamin D concentrations and behavioural, emotional and language outcomes... ...

        Research

        A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxin

        Suggests that IL-1R1 expression provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection. ...

        Research

        T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

        To show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy. ...

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