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        Research

        Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infant

        Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from <21 weeks' gestation to six months' post-partum, in a double-blinded, randomised placebo-controlled trial.  ...

        Research

        Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control study

        Cutaneous squamous cell carcinoma is a significant cause of morbidity for immunosuppressed patients such as organ transplant recipients; however, histological parameters which predict the likelihood of tumor progression are typically based on general population studies in which immunosuppressed patients represent only a small fraction of cases.  ...

        Research

        Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic Review

        Previous reports suggested that food proteins present in human milk (HM) may trigger symptoms in allergic children during breastfeeding, but existing evidence has never been reviewed systematically. ...

        Research

        Prebiotics: mechanisms and preventive effects in allergy

        In this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention ...

        Research

        Circulating Epithelial Cell Cytokines Are Associated With Early-Onset Atopic Dermatitis

        Debbie Susan Palmer Prescott D SL BSc BND PhD MBBS BMedSci PhD FRACP Head, Early Life & Life-Course Health Program; Team Lead, Nutrition in Early ...

        Research

        In-utero exposures and the evolving epidemiology of paediatric allergy

        This paper discusses the rising prevalence of allergic disease in children. This review article considers recent findings in the field of paediatric immune... ...

        Research

        In utero and postnatal vitamin D exposure and allergy risk

        This review article examines the evidence of the impact of in utero and postnatal vitamin D exposure on allergy risk in childhood ...

        Research

        Nutritional Influences on Epigenetic Programming. Asthma, Allergy, and Obesity

        Reliance on increasing use of dietary supplementation and fortification (eg, with folate) to compensate for increased consumption of processed foods is also... ...

        Research

        In “high-risk” infants with sufficient vitamin d status at birth, infant vitamin D supplementation had no effect on allergy outcomes: A randomized controlled trial

        Early infancy oral vitamin D supplementation does not appear to reduce the development of early childhood allergic disease ...

        Research

        The influence of sunlight exposure and sun protecting behaviours on allergic outcomes in early childhood

        The dramatic rise in allergic disease has occurred in tandem with recent environmental changes and increasing indoor lifestyle culture. While multifactorial, one consistent allergy risk factor has been reduced sunlight exposure. However, vitamin D supplementation studies have been disappointing in preventing allergy, raising possible independent effects of ultraviolet (UV) light exposure. ...

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