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        Research

        Fish oil supplementation in early infancy modulates developing infant immune responses

        Maternal fish oil supplementation during pregnancy has been associated with altered infant immune responses and a reduced risk of infant sensitization and... ...

        Research

        Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns

        We compared neonatal T reg from children born in western conditions (Australia) with those of neonates born in high microbial conditions (Papua New Guinea)... ...

        Research

        Nutritional approaches for the primary prevention of allergic disease: An update

        The dramatic rise in early childhood allergic diseases indicates the specific vulnerability of the immune system to early life environmental changes. ...

        Research

        Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens

        Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa. ...

        Research

        Changes to the Gut Microbiome in Young Children Showing Early Behavioral Signs of Autism

        The human gut microbiome has increasingly been associated with autism spectrum disorder (ASD), which is a neurological developmental disorder, characterized by impairments to social interaction. ...

        Research

        The challenges of developing and optimising an assay to measure 25-hydroxyvitamin D in saliva

        We have developed an LC-MS/MS assay that accurately measures saliva 25(OH)D3 levels, which correlated with serum levels ...

        Research

        Longitudinal egg-specific regulatory T- and B-cell development: Insights from primary prevention clinical trials examining the timing of egg introduction

        Egg allergy affects almost 1 in 10 Australian infants. Early egg introduction has been associated with a reduced risk in developing egg allergy; however, the immune mechanisms underlying this protection remain unclear. ...

        Research

        Pre-and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood

        The dramatic increase in the prevalence of allergic disease in recent decades reflects environmental and behavioural changes that have altered patterns of early immune development. The very early onset of allergic diseases points to the specific vulnerability of the developing immune system to environmental changes and the development of primary intervention strategies is crucial to address this unparalleled burden. ...

        Research

        iming of Introduction of Solids and Early-Onset Allergic Disease

        Strategies to prevent early-life food allergen sensitisation prior to commencement of solid foods are needed and should be the focus of future research ...

        Research

        Study protocol for a randomised controlled trial evaluating the effect of folic acid supplementation beyond the first trimester on maternal plasma unmetabolised folic acid in late gestation

        Taking folic acid containing supplements prior to and during early pregnancy reduces the risk of neural tube defects. Neural tube defects occur prior to 28 days postconception, after which, there is no proven benefit of continuing to take folic acid. However, many women continue to take folic acid containing supplements throughout the pregnancy. ...

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