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        Research

        Epigenetic modifications: Mechanisms of disease and biomarkers of food allergy

        The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. ...

        Research

        Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood

        Children of East Asian ancestry born in Australia have a higher burden of most allergic diseases in the first 6 years of life, whereas asthma may follow a different pattern ...

        Research

        Identifying gene network patterns and associated cellular immune responses in children with or without nut allergy

        Although evidence suggests that the immune system plays a key role in the pathophysiology of nut allergy, the precise immunological mechanisms of nut allergy have not been systematically investigated. The aim of the present study was to identify gene network patterns and associated cellular immune responses in children with or without nut allergy. ...

        Research

        Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy

        Peanut allergy is the the most common cause of life-threatening food-induced anaphylaxis. There is currently no effective long-term treatment. There is a pressing need for definitive treatments that improve the quality of life and prevent fatalities. Allergen oral immunotherapy (OIT) is a promising approach, which is effective at inducing desensitisation; however, OIT has a limited ability to induce sustained unresponsiveness (SU). ...

        Research

        Dysfunctional gut microbiome networks in childhood ige‐mediated food allergy

        The development of food allergy has been reported to be related with the changes in the gut microbiome, however the specific microbe associated with the pathogenesis of food allergy remains elusive. This study aimed to comprehensively characterize the gut microbiome and identify individual or group gut microbes relating to food-allergy using 16S rRNA gene sequencing with network analysis. ...

        News & Events

        WATCH: Professor Susan Prescott's allergy advice

        Allergy specialist Professor Susan Prescott gives her tips on how you can help prevent your child from developing a food allergy. ...

        Research

        Children of Asian ethnicity in Australia have higher risk of food allergy and early-onset eczema than those in Singapore

        In Western countries, Asian children have higher food allergy risk than Caucasian children. The early-life environmental exposures for this discrepancy are unclear. We aimed to compare prevalence of food allergy and associated risk factors between Asian children in Singapore and Australia. ...

        Research

        Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy

        Our data indicate epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex, and likely reflects pathways modified by gene-environment interactions in food allergy ...

        Research

        Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial

        To assess the efficacy and adverse events of epicutaneous immunotherapy with a peanut patch among peanut-allergic children ...

        Research

        Cellular and molecular mechanisms of vitamin D in food allergy

        Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis ...

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