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        Research

        Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case-control study of the association between pertussis vaccination in infancy

        We therefore speculate that removal of wP from the vaccine schedule contributed to the observed rise in IgE-mediated food allergy among Australian infants ...

        Research

        World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics

        Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20-30% in those with an allergic... ...

        Research

        T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

        To show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy. ...

        Research

        The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood

        This study examined whether maternal and/or fetal folate status in pregnancy is associated with infant allergic outcomes. ...

        Research

        Food Allergy

        Food allergies have become more common in our community, with up to one in ten young children now affected. Reactions can range from mild rashes to life threatening anaphylaxis and breathing difficulties. The most common food allergies are to egg, peanut, tree nuts, cow’s milk, fish, shellfish, wheat and soy. ...

        Research

        Immuno-epigenomic analysis identifies attenuated interferon responses in naïve CD4 T cells of adolescents with peanut and multi-food allergy

        IgE-mediated food allergies have been linked to suboptimal naïve CD4 T (nCD4T) cell activation in infancy, underlined by epigenetic and transcriptomic variation. Similar attenuated nCD4T cell activation in adolescents with food allergy have also been reported, but these are yet to be linked to specific epigenetic or transcriptional changes. ...

        Research

        Gene-vitamin D interactions on food sensitization: A prospective birth cohort study

        It has been hypothesized that vitamin D deficiency (VDD) contributes to the development of food sensitization (FS) and then food allergy. ...

        Research

        Early life innate immune signatures of persistent food allergy

        Early life innate immune dysfunction may represent a key immunological driver and predictor of persistent food allergy in childhood ...

        Research

        Ovalbumin in breast milk is associated with a decreased risk of IgE-mediated egg allergy in children

        Showed for the first time that the presence of an egg-derived allergen in breast milk is associated with a reduced risk of egg allergy in children at 2.5 years of age ...

        Research

        Early introduction of food reduces food allergy – Pro and Con

        When an infant is developmentally ready, a variety of nutritious foods should be introduced including the ‘more allergenic’ foods during infancy ...

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