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        Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens

        Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa. ...

        Research

        In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c mice

        The aim of this study was to assess whether in utero tobacco smoke exposure alone affects early-life lung growth and development. Pregnant BALB/c mice... ...

        Research

        Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection

        Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung... ...

        Research

        Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity

        In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. ...

        Research

        Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

        HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

        Research

        Early life rhinovirus infection exacerbates house-dust-mite induced lung disease more severely in female mice

        Early life rhinovirus infection influences the development of house-dust-mite induced lung disease in female, but not male mice ...

        Research

        Intrauterine growth restriction affects diaphragm function in adult female and male mice

        Sex and intrauterine growth restriction independently affect diaphragm contraction in adult mice without changes in structure ...

        Research

        Mouse Lung Structure and Function after Long-Term Exposure to an Atmospheric Carbon Dioxide Level Predicted by Climate Change Modeling

        Climate change models predict that atmospheric carbon dioxide [CO2] levels will be between 700 and 900 ppm within the next 80yrs. In this study we aimed to assess the respiratory structure and function effects of long-term exposure to 890ppm CO2 from preconception to adulthood using a mouse model. ...

        Research

        Editorial overview: Endocrine and metabolic adaptations to extreme environments: Living life to the extreme – insights into the limits of life and transitions to disease

        The need to understand responses to extreme environments has prompted this edition of Current Opinion in Endocrine and Metabolic Research ...

        Research

        Stiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient Hydrogels

        In obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood. ...

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