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        Research

        Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies

        A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF ...

        Research

        Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

        These findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or structural lung disease ...

        Research

        The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

        Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection ...

        Research

        Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients

        Our data illustrate that rhinovirus infection is capable of infecting upper and lower airway epithelial cells, driving cell death and inflammation ...

        Research

        Of pigs, mice, and men: Understanding early triggers of cystic fibrosis lung disease

        Understanding early triggers of Cystic Fibrosis Lung Disease ...

        Research

        Quorum Sensing Signaling Alters Virulence Potential and Population Dynamics in Complex Microbiome-Host Interactomes

        Genome sequencing and phylogenetic analysis of a quorum sensing positive Psychrobacter isolate identified several quorum sensing associated systems ...

        Research

        Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

        To evaluate lung disease progression using AA dimensions on chest CT over 2-years in young CF patients longitudinally and compare to disease controls. ...

        Research

        Airway surface liquid pH is not acidic in children with cystic fibrosis

        Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting. ...

        Research

        Determinants of culture success in an airway epithelium sampling program of young children with cystic fibrosis

        Determinants of culture success through retrospective analysis of a program of routinely brushing children with Cystic Fibrosis airway disease ...

        Research

        Assessment of early bronchiectasis in young children with cystic fibrosis is dependent on lung volume

        The aim of this study was to determine whether assessment of early CT scan-detected bronchiectasis in young children with cystic fibrosis (CF) depends on... ...

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